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首页> 外文期刊>European journal of pediatric surgery = Zeitschrift fur Kinderchirurgie >A National Long-Term Study of Neuroendocrine Tumors of the Appendix in Children: Are We Too Aggressive?
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A National Long-Term Study of Neuroendocrine Tumors of the Appendix in Children: Are We Too Aggressive?

机译：对儿童附录神经内分泌肿瘤的全国长期研究：我们太激进了吗？

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Introduction Pediatric neuroendocrine tumors (NETs) of the appendix are mostly detected incidentally after appendectomy for acute appendicitis. NET management is a matter of controversy. In this national, multicenter study, we aimed to establish guidelines based on our results and the literature. Materials and Methods Medical records of children (0-16 years) with NET of the appendix, treated in Switzerland (1991-2012), were reviewed. Results Forty cases (28 girls) were analyzed. Median age at diagnosis was 12.7 years (interquartile range [IQR]: 4.0). Tumor size was 0.1-24 mm (median: 0.6, IQR: 0.6). Four patients (10%) underwent additional surgery because of either tumor size > 15 mm (1/4), extension to the mesoappendix (1/4), or incomplete resection (2/4). Three patients with a tumor of >= 20 mm had no additional surgery. No patient had lymph node metastases. All patients were in complete remission at the last follow-up (median: 3.0 years, IQR: 10.9). Conclusion We conclude from this study and from an extensive review of the literature that two criteria may point to the need for additional surgery, i.e., the possibility of regional lymph node involvement: tumor size > 20 mm and incomplete surgical resection margins. Childhood NET of the appendix has an excellent prognosis.
机译：急性阑尾炎阑尾切除后，附录的儿科神经内分泌肿瘤（网）主要检测到急性阑尾炎。网络管理是一个争议的问题。在本国家，多中心研究中，我们旨在根据我们的结果和文献建立指导方针。综述了瑞士（1991-2012）附录净额（0-16岁）的材料和方法医疗记录（0-16岁）。结果分析了四十例（28名女孩）。诊断中位年龄为12.7岁（局部范围[IQR]：4.0）。肿瘤大小为0.1-24毫米（中位数：0.6，IQR：0.6）。由于肿瘤大小> 15mm（1/4），延伸到MesoAppendix（1/4），或不完全切除（2/4），4名患者（10％）接受额外的手术。肿瘤的三名患者> = 20 mm没有额外的手术。没有患者有淋巴结转移。所有患者均在最后一次随访中完全缓解（中位数：3.0年，IQR：10.9）。结论我们从本研究中得出结论，以及对文献的广泛审查，这两个标准可能指出额外手术的需要，即区域淋巴结受累的可能性：肿瘤大小> 20毫米和手术切除不完全。庭院净的附录预后具有优异的预后。

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