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首页> 外文期刊>Immunology: An Official Journal of the British Society for Immunology >CD4(+)CD25(+)GARP(+) regulatory T cells display a compromised suppressive function in patients with dilated cardiomyopathy
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CD4(+)CD25(+)GARP(+) regulatory T cells display a compromised suppressive function in patients with dilated cardiomyopathy

机译：CD4（+）CD25（+）Garp（+）调节T细胞显示扩张心肌病患者的受损抑制功能

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摘要

Dilated cardiomyopathy (DCM) is a lethal inflammatory heart disease and closely connected with dysfunction of the immune system. Glycoprotein A repetitions predominant (GARP) expressed on activated CD4(+) T cells with suppressive activity has been established. This study aimed to investigate the frequency and function of circulating CD4(+)CD25(+)GARP(+) regulatory T (Treg) cells in DCM. Forty-five DCM patients and 46 controls were enrolled in this study. There was a significant increase in peripheral T helper type 1 (Th1) and Th17 number and their related cytokines [interferon- (IFN-), interleukin (IL-17)], and an obvious decrease in Treg number, transforming growth factor-(1) (TGF-(1)) levels and the expression of forkhead box P3 (FOXP3) and GARP in patients with DCM compared with controls. In addition, the suppressive function of CD4(+)CD25(+)GARP(+) Treg cells was impaired in DCM patients upon T-cell receptor stimulation detected using CFSE dye. Lower level of TGF-(1) and higher levels of IFN- and IL-17 detected using ELISA were found in supernatants of the cultured CD4(+)CD25(+)GARP(+) Treg cells in DCM patients compared with controls. Together, our results indicate that CD4(+)CD25(+)GARP(+) Treg cells are defective in DCM patients and GARP seems to be a better molecular definition of the regulatory phenotype. Therefore, it might be an attractive stategy to pay more attention to GARP in DCM patients.
机译：扩张的心肌病（DCM）是一种致命的炎症性心脏病，与免疫系统的功能障碍密切相关。糖蛋白在具有抑制活性的活化的CD4（+）T细胞上表达的重复（Garp）已经确定。本研究旨在研究DCM中循环CD4（+）CD25（+）Garp（+）调节T（Treg）细胞的频率和功能。本研究报名参加45例DCM患者和46例对照。外周T辅助型1（TH1）和TH17号和其相关细胞因子[干扰素 - （IFN-），白细胞介素（IL-17）]的显着增加，以及TREG编号的明显降低，转化生长因子 - （ 1）（TGF-（1））与对照相比，DCM患者的叉头箱P3（Foxp3）和Garp的表达和Garp的表达。此外，在使用CFSE染料检测到的T细胞受体刺激时，DCM患者损害CD4（+）CD25（+）Garp（+）Treg细胞的抑制功能。与对照相比，在DCM患者中培养的CD4（+）CD25（+）Treg细胞的上清液中发现使用ELISA检测到使用ELISA的较低水平的TGF-（1）和更高水平的IFN-和IL-17。我们的结果在一起表明CD4（+）CD25（+）Garp（+）Treg细胞在DCM患者中有缺陷，Garp似乎是调节表型的更好分子定义。因此，在DCM患者中更加关注Garp可能是一个有吸引力的状态。

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  • 作者

    Wei Yuzhen; Yu Kunwu; Wei Hui; Su Xin; Zhu Ruirui; Shi Huairui; Sun Haitao; Luo Quan; Xu Wenbin; Xiao Junhui; Zhong Yucheng; Zeng Qiutang;

  • 作者单位

    Huahzong Univ Sci &

    Technol Lab Cardiovasc Immunol Inst Cardiol Union Hosp TongJi Med Coll;

    Huahzong Univ Sci &

    Technol Lab Cardiovasc Immunol Inst Cardiol Union Hosp TongJi Med Coll;

    First Peoples Hosp Tianmen City Tianmen Peoples R China;

    Huahzong Univ Sci &

    Technol Lab Cardiovasc Immunol Inst Cardiol Union Hosp TongJi Med Coll;

    Huahzong Univ Sci &

    Technol Lab Cardiovasc Immunol Inst Cardiol Union Hosp TongJi Med Coll;

    Huahzong Univ Sci &

    Technol Lab Cardiovasc Immunol Inst Cardiol Union Hosp TongJi Med Coll;

    Huahzong Univ Sci &

    Technol Lab Cardiovasc Immunol Inst Cardiol Union Hosp TongJi Med Coll;

    Huahzong Univ Sci &

    Technol Lab Cardiovasc Immunol Inst Cardiol Union Hosp TongJi Med Coll;

    Huahzong Univ Sci &

    Technol Lab Cardiovasc Immunol Inst Cardiol Union Hosp TongJi Med Coll;

    Huahzong Univ Sci &

    Technol Lab Cardiovasc Immunol Inst Cardiol Union Hosp TongJi Med Coll;

    Huahzong Univ Sci &

    Technol Lab Cardiovasc Immunol Inst Cardiol Union Hosp TongJi Med Coll;

    Huahzong Univ Sci &

    Technol Lab Cardiovasc Immunol Inst Cardiol Union Hosp TongJi Med Coll;

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  • 正文语种 eng
  • 中图分类 医学免疫学;
  • 关键词

    dilated cardiomyopathy; glycoprotein A repetitions predominant; immune system; regulatory T cells;

    机译：扩张心肌病;糖蛋白的重复占主导地位;免疫系统;监管T细胞;

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