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首页> 外文期刊>European thyroid journal >Regression of Papillary Thyroid Cancer during Nivolumab for Renal Cell Cancer
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Regression of Papillary Thyroid Cancer during Nivolumab for Renal Cell Cancer

机译:乳头状甲状腺癌在肾细胞癌中的乳头状甲状腺癌的回归

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摘要

Immune checkpoint inhibitors have been recently approved for cancer treatment. Nivolumab is a monoclonal antibody specific for programmed cell death-1 (PD-1) that modulates T-cell response. It was initially used for the treatment of malignant melanoma and then approved in other cancers, such as non-small cell lung cancer and clear cell renal cell carcinoma (ccRCC). So far, the activity of nivolumab in patients with thyroid malignancies has been reported in a single case of anaplastic thyroid cancer. Here, we report the case of a patient with ccRCC who developed a papillary thyroid carcinoma (PTC) under first-line sunitinib treatment. During nivolumab, the second-line treatment for ccRCC, we unexpectedly observed a complete regression of PTC.
机译:最近已批准免疫检查点抑制剂用于癌症治疗。 Nivolumab是针对编程的细胞死亡-1(PD-1)的单克隆抗体,其调节T细胞反应。 最初用于治疗恶性黑色素瘤,然后在其他癌症中批准,例如非小细胞肺癌和透明细胞肾细胞癌(CCRCC)。 到目前为止,在甲状腺型甲状腺癌的单一情况下报道了甲状腺恶性肿瘤患者中Nivolumab的活性。 在这里,我们通过CCRCC举行患者在第一线Sunitinib治疗中开发乳头状甲状腺癌(PTC)的患者。 在Nivolumab期间,对CCRCC的二线治疗,我们意外地观察到PTC的完全回归。

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