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首页> 外文期刊>Experimental and therapeutic medicine >Expression and correlation of Twist and gelatinases in breast cancer
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Expression and correlation of Twist and gelatinases in breast cancer

机译：乳腺癌捻和明胶酶的表达及相关性

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Altered expression of Twist, matrix metalloproteinase (MMP)-2 and MMP-9 proteins has been identified in various types of human cancers. However, the correlation between Twist and these gelatinases in breast cancer remains unclear. In this study, immunohistochemical analysis of Twist, MMP-2 and MMP-9 expression was performed on tissue microarrays from 200 breast cancer cases. The association of Twist and gelatinase expression with clinicopathological factors and patient survival was analyzed. Altered expression of Twist, MMP-2 and MMP-9 proteins was observed in breast cancer tissue. The positive rates of Twist, MMP-2 and MMP-9 protein expression were 75.5, 97.0 and 96.0%, respectively. Increased expression of Twist was positively correlated with the status of axillary lymph node metastasis and higher tumor-node-metastasis (TNM) stage (P<0.01). Moreover, increased expression of Twist was correlated with poor overall survival (OS) and post-operative relapse-free survival (RFS), compared with those for the patients with reduced expression levels of Twist (P<0.05, P<0.01). The expression of MMP-2 and MMP-9 was positively correlated with Twist expression (P<0.001). Our results indicate that Twist may play an important role in the invasion, metastasis and prognosis of breast cancer. Additionally, our results suggest that Twist may be a regulator of gelatinases (MMP-2 and MMP-9).
机译：已经在各种类型的人类癌症中鉴定了改变的扭曲的表达，基质金属蛋白酶（MMP）-2和MMP-9蛋白。然而，扭曲与乳腺癌中的明胶酶之间的相关性仍然不清楚。在该研究中，对200名乳腺癌病例的组织微阵列进行扭曲，MMP-2和MMP-9表达的免疫组化分析。分析了与临床病理因子和患者存活的扭曲和明胶酶表达的关系。在乳腺癌组织中观察到改变的捻度，MMP-2和MMP-9蛋白。扭曲，MMP-2和MMP-9蛋白表达的阳性率分别为75.5,97.0和96.0％。随着腋窝淋巴结转移的状态和肿瘤节点转移（TNM）阶段（P <0.01）的状态呈正相关（P <0.01），扭曲表达呈正相关（P <0.01）。此外，与减少表达水平扭曲的患者的患者相比，随着总体存活率差（OS）和无术后复发存活（RFS）的扭曲表达增加了（术后复发存活率（P <0.05，P <0.01）。 MMP-2和MMP-9的表达与扭曲表达呈正相关（P <0.001）。我们的结果表明，扭曲可能在​​乳腺癌的侵袭，转移和预后发挥重要作用。此外，我们的结果表明扭曲可以是明胶酶的调节剂（MMP-2和MMP-9）。

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