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首页> 外文期刊>Experimental and therapeutic medicine >Effect of Lycopersicon esculentum extract on apoptosis in the rat cerebellum, following prenatal and postnatal exposure to an electromagnetic field
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Effect of Lycopersicon esculentum extract on apoptosis in the rat cerebellum, following prenatal and postnatal exposure to an electromagnetic field

机译：Lycopersicon Esculentum提取物对大鼠细胞凋亡的影响，产前和产后产前暴露于电磁场

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The expansion of mobile phone technology has raised concerns regarding the effect of 900-MHz electromagnetic field (EMF) exposure on the central nervous system. At present, the developing human brain is regularly exposed to mobile telephones, pre- and postnatally. Several studies have demonstrated the acute effects of EMF exposure during pre- or postnatal periods; however, the chronic effects of EMF exposure are less understood. Thus, the aim of the present study was to determine the chronic effects of EMF on the pre- and postnatal rat cerebellum. The control group was maintained in the same conditions as the experimental groups, without the exposure to EMF. In the EMF1 group, the rats were exposed to EMF during pre- and postnatal periods (until postnatal day 80). In the EMF2 group, the rats were also exposed to EMF pre- and postnatally; in addition, however, they were provided with a daily oral supplementation of Lycopersicon esculentum extract (similar to 2 g/kg). The number of caspase-3-labeled Purkinje neurons and granule cells present in the rats in the control and experimental groups were then counted. The neurodegenerative changes were studied using cresyl violet staining, and these changes were evaluated. In comparison with the control animals, the EMF1 group demonstrated a significant. increase in the number of caspase-3-labeled Purkinje neurons and granule cells present in the cerebellum (P0.001). However, in comparison with the EMF1 group, the EMF2 group exhibited significantly fewer caspase-3-labeled Purkinje neurons and granule cells in the cerebellum. In the EMF1 group, the Purkinje neurons were revealed to have undergone dark neuron degenerative changes. However, the presence of dark Purkinje neurons was reduced in the EMF2 group, compared with the EMF1 group. The results indicated that apoptosis and neurodegeneration in rats exposed to EMF during pre- and postnatal periods may be reduced with Lycopersicon esculentum extract therapy.
机译：移动电话技术的扩展提出了关于900-MHz电磁场（EMF）暴露在中枢神经系统上的影响的担忧。目前，开发的人脑定期暴露于移动电话，预先和后期。几项研究表明了在预期或后期的EMF暴露的急性作用;然而，EMF暴露的慢性效应较少理解。因此，本研究的目的是确定EMF在预后大鼠小脑小脑上的慢性效应。对照组保持在与实验组相同的条件下，没有暴露于EMF。在EMF1组中，大鼠在前期和产后期间暴露于EMF（直至产后第80天）。在EMF2组中，大鼠也预先和后期暴露于EMF;然而，另外，它们提供了每日口服补充的枸杞子骨膜提取物（类似于2g / kg）。然后计数在对照和实验组中存在于对照和实验组中存在的Caspase-3标记的Purkinje神经元和颗粒细胞的数量。使用甲酚紫色染色研究了神经退行性变化，评估这些变化。与对照动物相比，EMF1组表现出显着的。增加脑血酶-3-标记的普京神经元和存在于小脑中的颗粒细胞数量的数量（P <0.001）。然而，与EMF1组相比，EMF2组在小脑中表现出显着较少的Caspase-3标记的Purkinje神经元和颗粒细胞。在EMF1组中，露毗je神经元被揭示经过黑暗神经元退行性变化。然而，与EMF1组相比，EMF2组在EMF2组中降低了暗紫癜神经元的存在。结果表明，在后期和后期暴露于EMF的大鼠中的细胞凋亡和神经变性可能会用萘氏菌易脑卒中治疗治疗。

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