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首页> 外文期刊>Experimental and therapeutic medicine >Therapeutic effects of Salvia miltiorrhiza injection combined with telmisartan in patients with diabetic nephropathy by influencing collagen IV and fibronectin: A case-control study
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Therapeutic effects of Salvia miltiorrhiza injection combined with telmisartan in patients with diabetic nephropathy by influencing collagen IV and fibronectin: A case-control study

机译：Salvia Miltiorriorhiza注射用胶原肾病患者综合疗法患者的疗效效果，影响胶原素IV和纤连蛋白：一种案例对照研究

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Involvement of collagen IV (ColIV) and fibronectin (FN) in the occurrence and development of diabetic nephropathy (DN) and the effects of telmisartan and Salvia miltiorrhiza injection in the treatment of the patients were investigated. Two hundred and fifty-eight patients with stage IV DN were selected as the case group, and another 110 normal healthy subjects were incorporated as the control group. Involved patients were subdivided into different groups according to different treatment therapies; patients in the telmisartan group (T group) were given oral telmisartan; patients in the Salvia miltiorrhiza injection + telmisartan (S + T group) were administered with Salvia miltiorrhiza injection combined with telmisartan treatment, and there was a group of patients who received no intervention as the placebo group. After intervention, levels of glycemic indexes and renal damage indexes indicated downwards trends both in the T group and the S + T group when compared to the placebo group; besides, levels in the S + T group were much lower than those in the T group (all P0.05). Additionally, in comparison among the above three intervention groups, differences in the fasting blood glucose, 2 h post-prandial blood glucose, glycosylated hemoglobin, blood urea nitrogen, serum creatinine and urinary albumin excretion rate were significant after treatment (all P0.05). Further, before intervention, both Co1IV and FN in the urine were increased in the case group compared to the control group (all P0.05). After intervention, both levels were apparently decreased. There were remarkable differences of Co1IV and FN levels in the urine when compared among three different intervention groups after treatment (P0.05). Increased ColIV and FN levels may be partially responsible for the development of DN. Salvia miltiorrhiza injection with telmisartan have beneficial synergistic effects for DN patients through attenuating the increase in ColIV and FN, reversing hyperglycemia state and postponing ultrastructure changes of glomerular basement membrane.
机译：研究了胶原蛋白IV（Coliv）和纤连蛋白（FN）在糖尿病肾病（DN）的发生和发育中的参与以及替米沙坦和丹参的疗效在患者治疗中的疗效。选择两百五十八个阶段IV DN作为案例组，并且另外110个正常健康受试者纳入对照组。根据不同的治疗疗法，涉及患者被细分为不同的群体; Telmisartan Group（T组）的患者是泰尔·泰尔米斯坦特的;慕尼黑米斯蒂希亚注射液中的患者+ Telmisartan（S + T组）用丹参治疗施用丹参治疗，并有一群患者没有作为安慰剂组的干预。干预后，与安慰剂组相比，血糖指数和肾损伤指数的水平表明T组和S + T组下降趋势;此外，S + T组中的水平远低于T组（所有P <0.05）中的水平。另外，在上述三个干预组中，在处理后，相比之下，禁食血糖，2小时后血糖，2小时后血糖，糖基血红蛋白，血液尿素和尿红素蛋白酶排泄率显着。此外，在干预之前，与对照组（所有P <0.05）相比，尿液中尿液中的CO1iV和FN在壳体中增加。干预后，两个水平显然都减少了。在治疗后三种不同的干预组比较时，尿液中的CO1IV和FN水平显着差异（P <0.05）。增加的Coliv和Fn水平可以部分地负责DN的发展。 Salvia Miltiorrhiza注射用Telmisartan注射患者对DN患者的有益协同作用，通过衰减Coliv和Fn的增加，逆转高血糖状态和推迟肾小球基底膜的超微结构变化。

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