Elobixibat, the first-in-class Ileal Bile Acid Transporter inhibitor, for the treatment of Chronic Idiopathic Constipation

Miner Philip B. Jr.

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Elobixibat, the first-in-class Ileal Bile Acid Transporter inhibitor, for the treatment of Chronic Idiopathic Constipation

机译：Elobixibat，一流的髂骨胆汁酸转运蛋白抑制剂，用于治疗慢性特发性便秘

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Introduction: Elobixibat is the first in class ileal bile acid transporter (IBAT) inhibitor. IBAT inhibitors block ileal absorption of bile acids by: (1) interrupting the enterohepatic circulation of bile resulting in a fall in serum cholesterol and (2) increasing the delivery of bile acids into the colon. Increasing colonic bile acids causes mucosal fluid secretion and enhances colonic motor activity. Changes in colonic physiology may be useful in treating constipation.

机译：简介：Elobixibat是ILAL胆汁酸转运蛋白（IBAT）抑制剂的第一类。 Ibat抑制剂阻断胆汁酸的髂骨吸收：（1）中断胆汁胆固醇的肠溶血液循环，导致血清胆固醇的落入（2）增加胆汁酸进入结肠。增加的结肠胆汁酸导致粘膜流体分泌并增强结肠运动活性。结肠生理学的变化可用于治疗便秘。

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《Expert opinion on pharmacotherapy》 |2018年第12期|共8页
作者
Miner Philip B. Jr.;
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作者单位

Oklahoma Fdn Digest Res 1813 Coventry Lane Oklahoma City OK 73120 USA;

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原文格式 PDF
正文语种 eng
中图分类药学;
关键词
Elobixibat; A3309; ileal bile acid transporter; IBAT; IBAT inhibitor; chronic idiopathic constipation; functional constipation; cholerheic enteropathy;

机译：Elobixibat;A3309;髂骨胆汁酸转运蛋白;IBAT;IBAT抑制剂;慢性特发性便秘;功能性便秘;Cholerheic肠病;

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1. Elobixibat, the first-in-class Ileal Bile Acid Transporter inhibitor, for the treatment of Chronic Idiopathic Constipation [J] . Miner Philip B. Jr. Expert opinion on pharmacotherapy . 2018,第7a12期

机译：Elobixibat，一流的髂骨胆汁酸转运蛋白抑制剂，用于治疗慢性特发性便秘
2. Determining an optimal clinical dose of elobixibat, a novel inhibitor of the ileal bile acid transporter, in Japanese patients with chronic constipation: a phase II, multicenter, double-blind, placebo-controlled randomized clinical trial [J] . Atsushi Nakajima, Mitsunori Seki, Shinya Taniguchi Journal of gastroenterology . 2018,第4期

机译：在日本慢性便秘患者中确定Elobixibat的最佳临床剂量，Elobixibat是Elbeal胆汁酸转运蛋白的新抑制剂：II期，多中心，双盲，安慰剂随机临床试验
3. Effect of single and multiple doses of elobixibat, an ileal bile acid transporter inhibitor, on chronic constipation: A randomized controlled trial [J] . Kumagai Yuji, Amano Hideki, Sasaki Yoshinobu, British Journal of Clinical Pharmacology . 2018,第10期

机译：单药和多剂量Elobixibat，髂骨胆汁酸转运蛋白抑制剂，慢性便秘：随机对照试验
4. Treatment effect of acupuncture and electric stimulation on chronic constipation patients [C] . Chen Chien-Yue, Chen Jin-Run, Ke Min-Da, 2010 Asia Pacific Conference on Circuit and Systems . 2010

机译：针刺和电刺激治疗慢性便秘的效果
5. Ileal bile acid transporter inhibitors: A search for new, alternative cholesterol-lowering drugs using methods in pharmacology and information science. [D] . Root, Carolyn. 2005

机译：回肠胆汁酸转运蛋白抑制剂：使用药理学和信息科学方法寻找新的替代性降胆固醇药物。
6. Effect of single and multiple doses of elobixibat an ileal bile acid transporter inhibitor on chronic constipation: A randomized controlled trial [O] . Yuji Kumagai, Hideki Amano, Yoshinobu Sasaki, 2018

机译：单次和多次服用艾洛比西巴（一种回肠胆汁酸转运蛋白抑制剂）对慢性便秘的影响：一项随机对照试验
7. Effect of single and multiple doses of elobixibat, an ileal bile acid transporter inhibitor, on chronic constipation: A randomized controlled trial [O] . Yuji Kumagai, Hideki Amano, Yoshinobu Sasaki, 2018

机译：单药和多剂量Elobixibat，髂骨胆汁酸转运蛋白抑制剂，慢性便秘：随机对照试验

Elobixibat, the first-in-class Ileal Bile Acid Transporter inhibitor, for the treatment of Chronic Idiopathic Constipation

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