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首页> 外文期刊>Expert opinion on pharmacotherapy >Comparing the efficacy of benzodiazepines and serotonergic anti-depressants for adults with generalized anxiety disorder: A meta-analytic review
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Comparing the efficacy of benzodiazepines and serotonergic anti-depressants for adults with generalized anxiety disorder: A meta-analytic review

机译：比较苯二氮藻和血清奈良药抗抑郁药对具有广义焦虑症的疗效：META-分析综述

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Introduction: Generalized anxiety disorder (GAD) is a common form of anxiety disorder. Selective serotonin reuptake inhibitors (SSRIs), serotonin and norepinephrine reuptake inhibitors (SNRIs), and benzodiazepines (BZs) are the most commonly prescribed medications for GAD, but little is known about the relative efficacy of these pharmacological treatments. Areas covered: This study provides a meta-analytic review of the efficacy of these medications in the treatment of adults with GAD. A comprehensive literature search yielded 54 articles reporting 56 unique studies with 12,655 participants treated with either pill placebo (6,191 participants), SSRIs (16 trials, 2,712 participants), SNRIs (17 trials, 2,603 participants), or BZs (23 trials, 1,149 participants). The overall combined effect size was modest to moderate (Hedges’ g = 0.37, p < 0.0001). Effect sizes decreased significantly over time. SSRIs (Hedges’ g = 0.33) and SNRIs (Hedges’ g = 0.36) demonstrated significantly lower effect sizes than BZs (Hedges’ g = 0.50). These findings were not due to differences in treatment length or publication year. Expert opinion: The results of this study suggest that the most common forms of pharmacotherapy for adult GAD are moderately effective, with BZs being the most effective drug.
机译：简介：广义焦虑症（GAD）是一种常见的焦虑症。选择性血清素再摄取抑制剂（SSRIS），血清素和去甲肾上腺素再摄取抑制剂（SNRIS）和苯二氮卓类药物（BZS）是GAD最常见的药物药物，但关于这些药理学处理的相对效果很少。涵盖了地区：本研究提供了对这些药物治疗成虫的疗效的荟萃分析审查。综合文献搜索54篇报告56篇与药丸安慰剂（6,191名参与者），SSRIS（16项试验，2,712名参与者），SNRIS（17项试验，2,603名参与者）或BZS（23次试验，1,149名参与者）治疗的12,655名参与者）。整体组合效果大小适度（Hedges的G = 0.37，P <0.0001）。随着时间的推移，效果大小显着下降。 SSRIS（Hedges'G = 0.33）和SNRIS（Hedges'G = 0.36）效果大小明显低于BZS（Hedges'G = 0.50）。这些发现不是由于治疗长度或出版年份的差异。专家意见：本研究的结果表明，成人GAD的最常见形式的药物疗法是适度有效的，BZS是最有效的药物。

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