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首页> 外文会议>International Symposium on Catecholamines and Other Neurotransmitters in Stress >Serotonergic Systems, Anxiety, andAffective Disorder Focus on the Dorsomedial Part of the DorsalRaphe Nucleus
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Serotonergic Systems, Anxiety, andAffective Disorder Focus on the Dorsomedial Part of the DorsalRaphe Nucleus

机译：Serotonergics系统，焦虑，和缔肤症的重点关注核心核的背部部分

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Depressed suicide patients have elevated expression of neuronal tryptophan hydroxy-lase 2 (TPH2) mRNA and protein in midbrain serotonergic neurons, as well as increases in brain serotonin turnover. The mechanisms underlying these changes are uncertain, but increased TPH2 expression and serotonin turnover could result from genetic influences, adverse early life experiences, or acute stressful life events, all of which can alter serotonergic neurotransmission and have been implicated in determining vulnerability to major depression. Emerging evidence suggests that there are several different stress-related subsets of serotonergic neurons, each with a unique role in the integrated stress response. Here we review our current understanding of how genetic and environmental factors may influence TPH2 mRNA expression and serotonergic neurotransmission, focusing in particular on the dorsomedial part of the dorsal raphe nucleus. This subdivision of the dorsal raphe nucleus is selectively innervated by key forebrain structures implicated in regulation of anxiety states, it gives rise to projections to a distributed neural system mediating anxiety states, and serotonergic neurons within this subdivision are selectively activated by a number of stress- and anxiety-related stimuli. A better understanding of the anatomical and functional properties of specific stress- or anxiety-related serotonergic systems should aid our understanding of the neural mechanisms underlying the etiology of anxiety and affective disorders.
机译：压下自杀患者具有升高的表达的神经元色氨酸羟基化酶2（TPH2）的mRNA和蛋白在脑血清素神经元，以及在脑的血清素营业额增加。这些变化背后的机制是不确定的，但增加了TPH2表达和血清素的营业额可以从遗传的影响，不良的早期生活经历，或急性应激性生活事件，所有这些都可以改变血清素的神经传递和确定抑郁症的脆弱性有牵连导致。越来越多的证据表明，有血清素神经元的几个不同的压力相关的子集，每个模块在集成的应激反应具有独特的作用。这里，我们回顾我们当前的遗传和环境因素如何影响TPH2基因表达和血清素的神经传递的了解，特别侧重于中缝背核背内侧部分。中缝背核这种细分有选择地在焦虑状态的调节中涉及的关键前脑结构的神经支配，它产生了凸起的分布神经系统介导该细分内焦虑状态，和血清素神经元由多个应力被选择性地激活与焦虑相关的刺激。更好地了解具体的应力或焦虑相关的血清素系统的解剖和功能性的应援我们的焦虑和情感障碍的病因潜在的神经机制的理解。

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