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Pharmacotherapy for the prevention of malaria in pregnant women: currently available drugs and challenges

机译：用于预防孕妇疟疾的药物疗法：目前可用的药物和挑战

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Introduction: Malaria in pregnancy continues to be a significant public health burden globally, with over 100 million women at risk each year. Sulfadoxine-pyrimethamine (SP) is the only antimalarial recommended for intermittent preventive therapy in pregnancy (IPTp) but increasing parasite resistance threatens its viability. There are few other available antimalarial therapies that currently have sufficient evidence of tolerability, safety, and efficacy to replace SP. Areas covered: Novel antimalarial combinations are under investigation for potential use as chemoprophylaxis and in IPTp regimens. The present review summarizes currently available therapies, emerging candidate combination therapies, and the potential challenges to integrating these into mainstream policy. Expert opinion: Alternative drugs or combination therapies to SP for IPTp are desperately required. Dihydroartemisinin-piperaquine and azithromycin-based combinations are showing great promise as potential candidates for IPTp but pharmacokinetic data suggest that dose modification may be required to ensure adequate prophylactic efficacy. If a suitable candidate regimen is not identified in the near future, the success of chemopreventive strategies such as IPTp may be in jeopardy.
机译：简介：怀孕的疟疾持续全球公共卫生负担，每年有超过1亿岁的妇女。磺唑胺 - 吡米甲胺（SP）是妊娠（IPTP）间歇性预防治疗的唯一抗疟情况（IPTP），但增加寄生虫抗性威胁其可行性。少数其他可用的抗疟疗法目前具有足够的可耐受性，安全性和功效来取代SP的验证。所涵盖的区域：正在调查新的抗疟组合以潜在用作化学缺口和IPTP方案。本综述总结了目前可用的疗法，新兴候选人组合疗法，以及将这些潜在挑战整合到主流政策中。专家意见：针对IPTP的替代药物或对SP的组合疗法是迫切需要的。作为IPTP的潜在候选者，二氢氨基氨苄蛋白 - 哌啶和基于基于二霉素的组合表明药代动力学数据表明剂量修饰可能需要进行适当的预防疗效。如果在不久的将来未确定合适的候选方案，则IPTP等化学预防策略的成功可能在危险之中。

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