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首页> 外文期刊>Experimental Gerontology >The endocrine-brain-aging triad where many paths meet: female reproductive hormone changes at midlife and their influence on circuits important for learning and memory
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The endocrine-brain-aging triad where many paths meet: female reproductive hormone changes at midlife and their influence on circuits important for learning and memory

机译：内分泌脑老化的三合会在其中许多路径相遇：女性生殖激素在中期变化及其对学习和记忆很重要的影响

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摘要

Female mammals undergo natural fluctuations in sex steroid hormone levels throughout life. These fluctuations span from early development, to cyclic changes associated with the menstrual or estrous cycle and pregnancy, to marked hormone flux during perimenopause, and a final decline at reproductive senescence. While the transition to reproductive senescence is not yet fully understood, the vast majority of mammals experience this spontaneous, natural phenomenon with age, which has broad implications for long-lived species. Indeed, this post-reproductive life stage, and its transition, involves significant and enduring physiological changes, including considerably altered sex steroid hormone and gonadotropin profiles that impact multiple body systems, including the brain. The endocrine-brain-aging triad is especially noteworthy, as many paths meet and interact. Many of the brain regions affected by aging are also sensitive to changes in ovarian hormone levels, and aging and reproductive senescence are both associated with changes in memory performance. This review explores how menopause is related to cognitive aging, and discusses some of the key neural systems and molecular factors altered with age and reproductive hormone level changes, with an emphasis on brain regions important for learning and memory. (C) 2017 Published by Elsevier Inc.
机译：雌性哺乳动物在整个生命中进行性类固醇激素水平的自然波动。这些波动从早期发展中跨越，与月经或口析周期和妊娠相关的循环变化，在围栏期间标志着激素助焊剂，并在生殖衰老中的最终下降。虽然向生殖衰老的过渡尚未完全理解，但绝大多数哺乳动物经历了这种具有年龄的自发，自然现象，这对长寿物种具有广泛的影响。实际上，这种繁殖后的生命阶段及其过渡涉及显着和持久的生理变化，包括影响多个身体系统的性类固醇激素和促性腺激素曲线，包括大脑。内分泌脑老化三合会特别值得注意，因为许多道路相遇和互动。由于衰老影响的许多大脑区域对卵巢激素水平的变化也敏感，并且衰老和生殖衰老都与记忆性能的变化有关。该审查探讨了更年期与认知老化有多相关的，并且讨论了随着年龄和生殖激素水平改变的一些关键神经系统和分子因素，并强调对学习和记忆重要的重要性。 （c）2017年由elsevier公司发布

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