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首页> 外文期刊>Brain research >Impact of adrenal hormones, reproductive aging, and major depression on memory circuitry decline in early midlife
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Impact of adrenal hormones, reproductive aging, and major depression on memory circuitry decline in early midlife

机译：肾上腺激素，生殖老化和重大抑郁对早期中期内存电路的影响

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Dehydroepiandrosterone-sulfate (DHEAS) is an adrenal androgen that is, in part, aromatized to estradiol. It continues to be produced after menopause and provides estrogenicity after depletion of ovarian hormones. Estradiol depletion contributes to memory circuitry changes over menopause, including changes in hippocampal (HIPP) and dorsolateral- and ventrolateral-prefrontal cortex (DLPFC; VLPFC) function. Further, major depressive disorder (MDD) patients have, in general, lower levels of estradiol and lower DHEAS than healthy controls, thus potentially a higher risk of adverse menopausal outcomes. We investigated whether higher DHEAS levels after menopause is associated with better memory circuitry function, especially in women with MDD. 212 adults (ages 45-55, 50% women) underwent clinical and fMRI testing. Participants performed a working memory (WM) N-back task and an episodic memory verbal encoding (VE) task during fMRI scanning. DHEAS levels were significantly associated with memory circuitry function, specifically in MDD postmenopausal women. On the WM task, lower DHEAS levels were associated with increased HIPP activity. On the VE task, lower DHEAS levels were associated with decreased activity in the HIPP and VLPFC. In contrast, there was no association between DHEAS levels and memory circuitry function in MDD pre/perimenopausal women, men, and non-MDD participants regardless of sex and reproductive status. In fact, MDD postmenopausal women with higher levels of DHEAS were similar to MDD pre/perimenopausal women and men. Thus, memory circuitry deficits associated with MDD and a lower ability of the adrenal gland to produce DHEAS after menopause may contribute to a lower ability to maintain intact memory function with age.
机译：脱氢哌啶酮 - 硫酸盐（DHEAS）是肾上腺雄激素，其部分是芳族芳族化。在更年期后继续生产，并在卵巢激素耗尽后提供雌激素。雌二醇耗尽有助于对更年期的内存电路改变，包括海马（HIPP）和背侧层和腹侧前额定皮层（DLPFC; VLPFC）功能的变化。此外，主要抑郁症（MDD）患者通常具有较低水平的雌二醇和低DHEAS，而不是健康的对照，因此可能具有更高的流体不良患者的患者。我们调查了更年期后更高的DHEAS水平是否与更好的内存电路功能相关，尤其是MDD的女性。 212名成人（45-55岁，50％妇女）接受临床和FMRI测试。参与者在FMRI扫描期间执行了一个工作存储器（WM）N背部任务和一个epiSodic Memory语言编码（VE）任务。 DHEAS水平与内存电路功能显着相关，特别是在MDD绝经期妇女中。在WM任务上，降低DHEAS水平与增加的HIPP活动相关。在VE任务上，降低DHEAS水平与HIPP和VLPFC中的活动减少有关。相比之下，在MDD前/周期妇女，男性和非MDD参与者中，DHEAS水平和内存电路功能之间没有关联，无论性和生殖状态如何。事实上，具有较高水平DHEAS水平的MDD绝育术女性与MDD前/周末妇女和男性相似。因此，与MDD相关的存储器电路缺陷和肾上腺在更年期后产生DHEAs的较低能力可能有助于较低的能够随着年龄维持完整内存功能的能力。

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