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Visfatin as a therapeutic target for rheumatoid arthritis

机译：类试素作为类风湿性关节炎的治疗靶标

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ABSTRACT Introduction: The rising prevalence of musculoskeletal pathologies in developed countries has caused a dramatic impact on social welfare. Amidst these musculoskeletal pathologies is Rheumatoid arthritis (RA), a chronic systemic autoimmune disease that mostly affects the synovium. RA metabolic-associated alterations, including distorted adipokine production, enhance RA inflammatory environment. Among the altered adipokines, visfatin is particularly involved in RA inflammation and catabolism and stands out as an essential enzyme linked to critical cell features. Areas covered: We discuss the potential mechanism supporting the contribution of visfatin to RA and the association between RA and obesity. We discuss the repurposing of cancer-tested drugs to inhibit visfatin in the context of RA. Additionally, we address the possibility of combining these drugs with current RA therapy. Finally, we explore the future of visfatin as an RA biomarker or therapeutic target. Expert opinion: Inhibition of visfatin has become an interesting therapeutic approach for RA pathology. Such a feat has already been attained in oncology using small molecule inhibitors, which suggest that a similar course of action would be worth pursuing in the RA context. Visfatin will become an important biomarker and therapeutic target for RA.
机译：摘要介绍：发达国家肌肉骨骼病理的普遍性引起对社会福利的巨大影响。在这些肌肉骨骼病理学中是类风湿性关节炎（RA），一种主要影响Synovium的慢性全身自身免疫疾病。 Ra代谢相关的改变，包括抗扭的己酮生产，增强RA炎症环境。在改变的adipokines中，类毒素特别参与Ra炎症和分解代谢，并作为与关键细胞特征有关的基本酶。所涵盖的领域：我们讨论了支持visfatin与Ra和Ra和肥胖之间的关联贡献的潜在机制。我们讨论了在RA的背景下抑制癌症测试药物以抑制缺失的毒素。此外，我们解决了将这些药物与当前的RA治疗组合的可能性。最后，我们探讨了visfatin作为ra Biomarker或治疗目标的未来。专家意见：抑制visuatin已成为RA病理学的有趣治疗方法。使用小分子抑制剂肿瘤学已经达到了这种壮举，这表明类似的行动方案值得在RA语境中追求。 visfatin将成为RA的重要生物标志物和治疗靶标。

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