Fibroblast activation protein-alpha in fibrogenic disorders and cancer: more than a prolyl-specific peptidase?

Juillerat-Jeanneret Lucienne; Tafelmeyer Petra; Golshayan Dela

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Fibroblast activation protein-alpha in fibrogenic disorders and cancer: more than a prolyl-specific peptidase?

机译：成纤维细胞活化蛋白-α在纤维纤维疾病和癌症中：多于脯氨酰肽酶？

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Introduction: Fibroblast activation protein-alpha (FAP-alpha) belongs to the family of prolyl-specific serine proteases. FAP-alpha displays both exopeptidase and endopeptidase/gelatinase/collagenase activities. FAP-alpha protein and/or activity have been associated with fibrosis, inflammation and cancer, but the protein is undetectable in most normal tissues. FAP-alpha is selectively expressed at sites of tissue remodeling and repair and enhances tumor progression, suggesting that this protease may be a therapeutic target to treat human disorders associated with fibrotic dysregulation.

机译：引言：成纤维细胞活化蛋白-α（FAP-α）属于含有含量特异性丝氨酸蛋白酶的系列。 FAP-α显示外肽酶和内肽酶/凝胶酶/胶原酶活性。 FAP-α蛋白和/或活性与纤维化，炎症和癌症有关，但在大多数正常组织中蛋白质是不可检测的。 FAP-α在组织重塑和修复的部位选择性地表达并增强肿瘤进展，表明该蛋白酶可以是治疗与纤维化多粒细胞相关的人类疾病的治疗靶标。

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来源
《Expert opinion on therapeutic targets》 |2017年第12期|共15页
作者
Juillerat-Jeanneret Lucienne; Tafelmeyer Petra; Golshayan Dela;
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作者单位

CHU Vaudois Transplantat Ctr Lausanne Switzerland;

Hybrigen Serv Labs &

Headquarters Paris France;

CHU Vaudois Transplantat Ctr Lausanne Switzerland;

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原文格式 PDF
正文语种 eng
中图分类药学;
关键词
Cancer; fibroblast activation protein-alpha; FAP-alpha; fibrosis; inflammation; inhibitors; therapy;

机译：癌症;成纤维细胞活化蛋白-α;FAP-α;纤维化;炎症;抑制剂;治疗;

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1. Fibroblast activation protein-alpha in fibrogenic disorders and cancer: more than a prolyl-specific peptidase? [J] . Juillerat-Jeanneret Lucienne, Tafelmeyer Petra, Golshayan Dela Expert opinion on therapeutic targets . 2017,第7a12期

机译：成纤维细胞活化蛋白-α在纤维纤维疾病和癌症中：多于脯氨酰肽酶？
2. Coupled expression of dipeptidyl peptidase-IV and fibroblast activation protein-alpha in transformed astrocytic cells. [J] . Balaziova E, Busek P, Stremenova J, Molecular and Cellular Biochemistry: An International Journal for Chemical Biology . 2011,第1a2期

机译：二肽基肽酶-IV和成纤维细胞活化蛋白-α在转化的星形细胞中的联合表达。
3. Fibroblast activation protein-alpha in tumor cells promotes colorectal cancer angiogenesis via the Akt and ERK signaling pathways [J] . Cao Feng, Wang Songsong, Wang Huanqin, Molecular medicine reports . 2018,第2aPta1期

机译：肿瘤细胞中成纤维细胞活化蛋白-α通过AKT和ERK信号通路促进结肠直肠癌血管生成
4. Cancer-associated fibroblast expression of serine protease fibroblast activation protein increases tumour metastatic potential and alters cell death mechanisms [C] . Baird S.K., Rentier C., Smyth F.E Incorporating of the Australian Society for Biochemistry and Molecular Biology Combio . 2009

机译：丝氨酸蛋白酶成纤维细胞活化蛋白的癌症相关的成纤维细胞表达增加了肿瘤转移性潜力和改变细胞死亡机制
5. An extracellular transmembrane peptidase expressed during wound healing is a tumor suppressor in melanocytic cells: The role of fibroblast activation protein alpha [D] . Ramirez-Montagut, Teresa. 2003

机译：伤口愈合过程中表达的细胞外跨膜肽酶是黑素细胞的肿瘤抑制因子：成纤维细胞活化蛋白α的作用
6. Mechanical signals regulate and activate SNAIL1 protein to control the fibrogenic response of cancer-associated fibroblasts [O] . Kun Zhang, Whitney R. Grither, Samantha Van Hove, -1

机译：机械信号调节并激活SNAIL1蛋白以控制与癌症相关的成纤维细胞的纤维化反应
7. FAP-alpha (Fibroblast activation protein-alpha) is involved in the control of human breast cancer cell line growth and motility via the FAK pathway [O] . Jia, Jun, Martin, Tracey Amanda, Ye, Lin, 2014

机译：FAP-alpha（成纤维细胞活化蛋白-alpha）通过FAK途径参与人类乳腺癌细胞株的生长和运动控制
8. Evaluation of Fibroblast Activation Protein-Alpha (FAP) as a Diagnostic Marker and Therapeutic Target in Prostate Cancer [R] . Brennen, N. 2009

机译：评估成纤维细胞活化蛋白-α（Fap）作为前列腺癌的诊断标志物和治疗靶标

Fibroblast activation protein-alpha in fibrogenic disorders and cancer: more than a prolyl-specific peptidase?

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