MELK: a potential novel therapeutic target for TNBC and other aggressive malignancies

Pitner Mary Kathryn; Taliaferro Juliana M.; Dalby Kevin N.; Bartholomeusz Chandra

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MELK: a potential novel therapeutic target for TNBC and other aggressive malignancies

机译：梅尔克：TNBC和其他侵略性恶性肿瘤的潜在新的治疗目标

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Introduction: There is an unmet need in triple-negative breast cancer (TNBC) patients for targeted therapies. Maternal embryonic leucine zipper kinase (MELK) is a promising target for inhibition based on the abundance of correlative and functional data supporting its role in various cancer types.

机译：介绍：针对有针对性疗法的三阴性乳腺癌（TNBC）患者有一个未满足的需求。母体胚亮氨酸拉链激酶（MEMK）是基于支持其在各种癌症类型中作用的丰富相关和功能数据的抑制靶标。

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《Expert opinion on therapeutic targets》 |2017年第12期|共11页
作者
Pitner Mary Kathryn; Taliaferro Juliana M.; Dalby Kevin N.; Bartholomeusz Chandra;
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作者单位

Univ Texas MD Anderson Canc Ctr Sect Translat Breast Canc Res Dept Breast Med Oncol Houston TX;

Univ Texas Austin Coll Pharm Div Med Chem Austin TX 78712 USA;

Univ Texas Austin Coll Pharm Div Med Chem Austin TX 78712 USA;

Univ Texas MD Anderson Canc Ctr Sect Translat Breast Canc Res Dept Breast Med Oncol Houston TX;

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原文格式 PDF
正文语种 eng
中图分类药学;
关键词
Breast cancer; cancer stem cells; EMT; MELK; metastasis; therapy resistance; TNBC;

机译：乳腺癌;癌症干细胞;EMT;梅尔克;转移;治疗抵抗;TNBC;

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专利

1. MELK: a potential novel therapeutic target for TNBC and other aggressive malignancies [J] . Pitner Mary Kathryn, Taliaferro Juliana M., Dalby Kevin N., Expert opinion on therapeutic targets . 2017,第7a12期

机译：梅尔克：TNBC和其他侵略性恶性肿瘤的潜在新的治疗目标
2. BRCA1 Mutations in Women with HGSOC and TNBC: Molecular Players that Drive Transformation as Potential Therapeutic Targets [J] . Footman Alexus, Rao Veena Journal of women’s health . 2016,第4期

机译：HGSOC和TNBC妇女的BRCA1突变：驱动转化为潜在治疗目标的分子参与者
3. Development of HumanSerine Protease-Based Therapeutics Targeting Fn14 and Identification of Fn14 as a New Target Overexpressed in TNBC [J] . Zhou Hong, Mohamedali Khalid A., Gonzalez-Angulo Ana Maria, Molecular cancer therapeutics . 2014,第11期

机译：以人丝氨酸蛋白酶为基础的针对Fn14的治疗方法的开发以及将Fn14鉴定为在TNBC中过表达的新靶标
4. Identification of Potentially Therapeutic Target Genes in Ovarian Cancer via Bioinformatic Approach [C] . Li Chengzhang, Xu Jiucheng IEEE International Conference on Bioinformatics and Computational Biology . 2021

机译：通过生物信息方法鉴定卵巢癌中的潜在治疗靶基因
5. FACT is an accelerator of tumorigenesis, a marker of aggressive, undifferentiated cancers, and a potential therapeutic target. [D] . Garcia, Henry Alexander. 2014

机译：FACT是肿瘤发生的促进剂，侵袭性，未分化癌症的标志物和潜在的治疗靶标。
6. Development of Human Serine Protease-based Therapeutics Targeting Fn14 and Identification of Fn14 as a New Target Overexpressed in TNBC [O] . Hong Zhou, Khalid A. Mohamedali, Ana Maria Gonzalez-Angulo, -1

机译：以人丝氨酸蛋白酶为基础的针对Fn14的治疗药物的开发以及将Fn14鉴定为在TNBC中过表达的新靶标
7. Effects of Hsp90 Inhibitors on Patient Derived Triple Negative Breast Cancer (TNBC) Cells: BRCA1 as a Therapeutic Target for TNBC [O] . Shrikant Anant, Prabhu Ramamoorthy, Ossama Tawfik, 2017

机译：HSP90抑制剂对患者衍生三重阴性乳腺癌（TNBC）细胞的影响：BRCA1作为TNBC的治疗靶标
8. Validation of MECP2 as a New Therapeutic Target in TNBC. [R] . Silver, D. P. 2016

机译：验证mECp2作为TNBC的新治疗靶标。

MELK: a potential novel therapeutic target for TNBC and other aggressive malignancies

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