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How little is known about the role of human FOXP3+ Tregs in tumors

机译:关于人Foxp3 + Tregs在肿瘤中的作用有多少点

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The accompanying review by Dr. Theresa Whiteside provides a thoughtful and erudite coverage of the importance of FOXP3 + T-regulatory (Treg) cells in cancer, including during therapy with immune checkpoint inhibitors [1]. This editorial briefly summarizes significant gaps in our knowledge of human FOXP3+ Tregs, especially in the context of anti-tumor immune responses, and will emphasize the need for investigators to characterize human Tregs directly rather than to assume that their phenotype and functions can be readily extrapolated from murine studies.
机译:博士博士Wheresa Whiteside的伴随审查提供了对癌症中Foxp3 + T-starmatory(Treg)细胞的重要性的深思熟虑和博学的覆盖,包括治疗免疫检查点抑制剂[1]。 这一点简要概述了我们对人Foxp3 + Tregs的知识的显着差距,特别是在抗肿瘤免疫反应的背景下,并强调需要调查人员直接表征人类Tregs,而不是假设它们的表型和功能可以易于推断 来自小鼠研究。

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