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首页> 外文期刊>General and comparative endocrinology >Ctrp9 and adiponectin receptors in Nile tilapia ( Oreochromis niloticus ): Molecular cloning, tissue distribution and effects on reproductive genes
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Ctrp9 and adiponectin receptors in Nile tilapia ( Oreochromis niloticus ): Molecular cloning, tissue distribution and effects on reproductive genes

机译：尼罗罗非鱼（Oreochromis Niloticus）中的Ctrp9和脂联素受体：分子克隆，组织分布和对生殖基因的影响

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摘要

As the close paralog of adiponectin, C1q/TNF-Related Protein 9 (CTRP9) has been reported to be involved in the regulation of glucose and fat metabolism, immunization and endothelial cell functions. However, information regarding the actions of Ctrp9 on reproduction is extremely limited in fish. As a first step, Ctrp9, adiponectin receptor 1 (Adipor1) and Adipor2 were identified from Nile tilapia. The open reading frame (ORF) ofctrp9was 1020?bp which encoded a 339 amino acids. Moreover, the ORFs ofadipor1andadipor2were 1131?bp and 1134?bp encoding 376 and 377 amino acids, respectively. Tissue distribution showed thatctrp9mRNA levels were highest in the kidney in both sexes. And, the expression ofadipor1andadipor2were widely distributed in all tissues examined, exhibiting high levels in the brain, gonad, gut and stomach. In addition, intraperitoneal (i.p.) injection of gCtrp9 (globular Ctrp9) suppressed the hypothalamic expression ofgnrh2(gonadotropin-releasing hormone 2) andgnrh3, as well asgthα(gonadotropic hormone α),fshβ(follicle-stimulating hormone β),lhβ(luteinizing hormone β),lhr(LH receptor) andfshr(FSH receptor) mRNA levels in the pituitary. The mRNA levels ofadipor1, but notadipor2, in the gonads were also inhibited after injection. Moreover, the levels of serum E2 (estrogen) in female and T (testosterone) in male were significantly decreased after injection of gCtrp9. Overall, our data provides novel data indicating, for the first time, a regulatory effect of CTRP9 on teleost reproduction.
机译：作为脂联素的紧密寄生虫，据报道，C1Q / TNF相关蛋白质9（CTRP9）参与调节葡萄糖和脂肪代谢，免疫和内皮细胞功能。然而，有关Ctrp9对繁殖的行动的信息非常有限。作为第一步，CtrP9，脂联素受体1（Adipor1）和Adipor2鉴定于尼罗罗非鱼。开放阅读框（ORF）OFCTRP9Was 1020？BP编码339个氨基酸。此外，ORFS ADIPOR1AddiPor2的ORFS 1131？BP和1134〜BP编码376和377氨基酸。组织分布显示，两性肾脏中的肾脏分布表明。并且，ADIPOR1Addipor2的表达在检查的所有组织中广泛分布，在大脑，Gonad，肠道和胃中表现出高水平。此外，腹膜内（IP）注射GCTRP9（球状CTRP9）抑制了GNRH2（促性腺激素释放激素2）和GNRH 3的下丘脑表达，以及ASGTHα（促型激素α），FSHβ（卵泡刺激激素β），LHβ（丁氏素激素β），LHR（LH受体）和FSHR（FSH受体）垂体MRNA水平。在注射后也抑制了在Gonad中的前普欧洲脂蛋白酶1，但NotaDipor2。此外，在注射GCTRP9后，雄性和T（睾酮）中血清E2（雌激素）的水平明显降低。总体而言，我们的数据首次提供了表明Ctrp9对Textost繁殖的监管效果的新型数据。

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  • 来源
    《General and comparative endocrinology》 |2018年第2018期|共14页
  • 作者

    Guokun Yang; Qinqin Song; Caiyun Sun; Jingkai Qin; Jirong Jia; Xi Yuan; Yazhou Zhang; Wensheng Li;

  • 作者单位

    State Key Laboratory of Biocontrol Institute of Aquatic Economic Animals and Guangdong Province;

    State Key Laboratory of Biocontrol Institute of Aquatic Economic Animals and Guangdong Province;

    State Key Laboratory of Biocontrol Institute of Aquatic Economic Animals and Guangdong Province;

    State Key Laboratory of Biocontrol Institute of Aquatic Economic Animals and Guangdong Province;

    State Key Laboratory of Biocontrol Institute of Aquatic Economic Animals and Guangdong Province;

    State Key Laboratory of Biocontrol Institute of Aquatic Economic Animals and Guangdong Province;

    State Key Laboratory of Biocontrol Institute of Aquatic Economic Animals and Guangdong Province;

    State Key Laboratory of Biocontrol Institute of Aquatic Economic Animals and Guangdong Province;

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  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类 内分泌腺疾病及代谢病;
  • 关键词

    Ctrp9; Adipor1/2; Reproduction; Tilapia;

    机译：Ctrip9;adipor1 / 2;繁殖;罗非鱼;

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