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首页> 外文期刊>Evidence-based complementary and alternative medicine: eCAM >The Antiapoptosis Effect of Geum japonicum Thunb. var. chinense Extracts on Cerebral Ischemia Reperfusion Injury via PI3K/Akt Pathway
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The Antiapoptosis Effect of Geum japonicum Thunb. var. chinense Extracts on Cerebral Ischemia Reperfusion Injury via PI3K/Akt Pathway

机译：Geum japonicum thunb的抗痘病作用。 var。 通过PI3K / AKT途径对脑缺血再灌注损伤的CHINENTS提取物

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摘要

Geum japonicum Thunb. var. chinense (GJ) is a type of wild vegetable found in China and other Asian countries; it has been reported that its extracts possess a neuroprotective effect against cerebral ischemia reperfusion (CIR) injury. The aim of this study is to explore the effect GJ extracts on transient focal CIR injury and neurons apoptosis and to clarify its possible underlying mechanisms in vivo. Our results indicated that pretreatment with GJ extracts significantly ameliorated the infarct volume, decreased neurological deficits, lessened neural cells apoptosis, downregulated GFAP activity level, and increased surviving neurons. Moreover, GJ extracts preadministration increased Bcl-2 levels and attenuated the increase in the expressions of Bax and it also lowered the cleaved caspase-3 activity in ischemic cortex tissues which was caused by CIR and increased the expression of PI3K and p-Akt. The above effects of high dose of GJ (GJ-H) group weremuch better than those of low dose of GJ (GJ-L), which indicated thatGJ extractsmay be helpful in the suppression of CIR injury with a dose-dependent manner.
机译：Geum japonicum thunb。 var。 Chinense（GJ）是中国和其他亚洲国家发现的一种野生蔬菜;据报道，其提取物具有针对脑缺血再灌注（CIR）损伤的神经保护作用。本研究的目的是探讨瞬态焦损损伤和神经元细胞凋亡的效果GJ提取物，并阐明其体内可能的潜在机制。我们的结果表明，GJ提取物的预处理显着改善了梗塞体积，降低了神经细胞凋亡，降低神经细胞凋亡，下调的GFAP活性水平，并增加存活的神经元。此外，GJ提取脂肪分子增加了Bcl-2水平并衰减了Bax表达的增加，并且它也降低了由CIR和增加PI3K和P-AKT的表达的缺血性皮层组织中的切割的caspase-3活性。高剂量GJ（GJ-H）组Weremuch的上述效果优于低剂量的GJ（GJ-L），这表明Athj提取物抑制具有剂量依赖性的方式有助于抑制CIR损伤。

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    Ou Bingjin; Tao Wei; Yang Songbai; Feng Jiateng; Wang Jinfeng; Yang Tong; Wu Hanyu; Huang Yaguang; Tan Lingjing; Huang Weifeng; Feng Zhitao; Mei Zhigang;

  • 作者单位

    China Three Gorges Univ Med Coll Grade Pharmacol Lab Chinese Med Approved State Ad Yichang;

    China Three Gorges Univ Med Coll Grade Pharmacol Lab Chinese Med Approved State Ad Yichang;

    China Three Gorges Univ Yichang Hosp Tradit Chinese Med Yichang 443003 Hubei Peoples R China;

    China Three Gorges Univ Med Coll Grade Pharmacol Lab Chinese Med Approved State Ad Yichang;

    China Three Gorges Univ Med Coll Grade Pharmacol Lab Chinese Med Approved State Ad Yichang;

    China Three Gorges Univ Med Coll Grade Pharmacol Lab Chinese Med Approved State Ad Yichang;

    China Three Gorges Univ Med Coll Grade Pharmacol Lab Chinese Med Approved State Ad Yichang;

    China Three Gorges Univ Med Coll Grade Pharmacol Lab Chinese Med Approved State Ad Yichang;

    China Three Gorges Univ Med Coll Grade Pharmacol Lab Chinese Med Approved State Ad Yichang;

    China Three Gorges Univ Med Coll Grade Pharmacol Lab Chinese Med Approved State Ad Yichang;

    China Three Gorges Univ Med Coll Grade Pharmacol Lab Chinese Med Approved State Ad Yichang;

    China Three Gorges Univ Med Coll Grade Pharmacol Lab Chinese Med Approved State Ad Yichang;

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  • 正文语种 eng
  • 中图分类 临床医学;
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