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Systemic analysis of the expression and prognostic significance of PAKs in breast cancer

机译：乳腺癌中PAK表达及预后意义的全身分析

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PAKs (p21-activated kinases) are reported to play crucial roles in a variety of cellular processes and participate in the progression of human cancers. However, the expression and prognostic values of PAKs remain poorly explored in breast cancers. In our study, we examined the mRNA and protein expression levels of PAKs and the prognostic value. We also analyzed the interaction network, genetic alteration, and functional enrichment of PAKs. The results showed that the mRNA levels of PAK1, PAK2, PAK4 and PAK6 were significantly up-regulated in breast cancer compared with normal tissues, while the reverse trend for PAK3 and PAK5 was found, furthermore, the proteins expression of PAK1, PAK2 and PAK4 in breast cancer tissues were higher than that in normal breast tissues. Survival analysis revealed breast cancer patients with low mRNA expression of PAK3 and PAK5 showed worse RFS, conversely, elevated PAK4 levels predicted worse RFS. In addition, the breast cancer patients with PAKs genetic alterations correlated with worse OS. These results indicated that PAKs might be promising potential biomarkers for breast cancer.
机译：据报道，PAKS（P21-活化的激酶）在各种细胞过程中起着至关重要的作用，并参与人类癌症的进展。然而，PAK的表达和预后价值仍然在乳腺癌中仍然很差。在我们的研究中，我们检查了PAK和预后价值的mRNA和蛋白表达水平。我们还分析了互动网络，遗传改变和Paks的功能丰富。结果表明，与正常组织相比，PAK1，PAK2，PAK4和PAK6的mRNA水平在乳腺癌中显着上调，而PAK3和PAK5的逆向趋势还被发现，此外，PAK1，PAK2和PAK4的蛋白质表达在乳腺癌组织中较正常乳腺组织中的癌组织。生存分析显示乳腺癌患者的乳腺癌患者的低mRNA表达PAK3和PAK5表现出较差的RFS，相反，PAK4水平升高预测RFS。此外，乳腺癌患者患有PAK的遗传改变与更严重的操作系统相关。这些结果表明，PAK可能是乳腺癌的潜在生物标志物。

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