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Effect of the key histone modifications on the expression of genes related to breast cancer

机译：关键组蛋白修饰对乳腺癌相关基因表达的影响

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Abnormal histone modifications (HMs) and transcription factors (TFs) can alter the expression of cancer-related genes to promote tumorigenesis. We studied the variations of 11 HMs and 2 TFs in human breast cancer cells (MCF-7) compared to human normal mammary epithelial cells (HMEC), and the effects of HMs/TFs in various regions of the genome on the expression changes of breast cancer-related genes. Based on HMs and TFs signals' differences between MCF-7 and HMEC flanking TSSs, the up- and down-regulated genes in MCF-7 were predicted by Random Forest, and important HMs and regions were found. Results indicate that H3K79me2, H3K27ac, and H3K4me1 are particularly important for the changes of gene expression in MCF-7. Especially, H3K79me2 around the 60-th bin flanking TSSs may be the key for regulating gene expression. Our studies reveal H3K79me2 may be a core HM for breast cancer.
机译：异常组蛋白修饰（HMS）和转录因子（TFS）可以改变癌症相关基因的表达以促进肿瘤发生。 与人常规乳腺上皮细胞（HMEC）相比，我们在人乳腺癌细胞（MCF-7）中研究了11 hms和2 TFS的变化，以及HMS / TFS在基因组的各种区域的影响对乳房的表达变化 与癌症相关的基因。 基于HMS和TFS信号在MCF-7和HMEC侧翼TSS之间的差异，随机林预测MCF-7中的上调和下调基因，并发现了重要的HMS和地区。 结果表明H3K79ME2，H3K27AC和H3K4ME1对于MCF-7中基因表达的变化尤为重要。 特别地，围绕60-Th侧翼TSSS的H3K79ME2可以是调节基因表达的关键。 我们的研究显示H3K79ME2可能是乳腺癌的核心HM。

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