...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Geriatrics & gerontology international. >Anticholinergic drugs use and risk of hip fracture in geriatric patients
【24h】

Anticholinergic drugs use and risk of hip fracture in geriatric patients

机译：抗胆碱能药物在老年患者中的使用和髋部骨折风险

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Aim Limited research exists regarding the effect of anticholinergic drugs on fracture in geriatric Japanese patients. The aim of the present study was to establish whether anticholinergic load affects hip fracture and to clarify the risk based on the Anticholinergic Risk Scale score among geriatric patients in a convalescent rehabilitation setting. Methods The present nested case–control study included consecutive geriatric patients admitted and discharged from the convalescent rehabilitation ward between 2010 and 2016. Participants were divided based on the presence or absence of hip fracture during hospitalization. Demographic data, laboratory data and the Functional Independence Measure were analyzed between groups. The primary outcome was the presence of hip fracture. Multiple logistic regression analysis was carried out to analyze the relationship between anticholinergic drug use and hip fracture. Results In total, 601 participants (210 men, 391 women; interquartile range 73–85 years) were included in the present study. Multiple logistic regression analysis of hip fracture, adjusting for confounding factors, showed that anticholinergic drug use was independently and positively correlated with hip fracture. In particular, an increase in the Anticholinergic Risk Scale score by 2 points correlates with a 2.86‐fold greater risk for hip fracture, and an increase of ≥3 points results in a 4.21‐fold greater risk, both being statistically significant results. Conclusion Increased anticholinergic load during hospitalization might be a predictor of increased hip fracture in geriatric patients. Geriatr Gerontol Int 2018; 18: 1340–1344 .
机译：目的有限研究存在抗胆碱能药物对老年人日本患者骨折的影响。本研究的目的是建立抗胆碱能载荷是否会影响髋骨骨折，并根据康复康复环境中的老年患者中的抗胆碱能风险评分阐明风险。方法目前嵌套病例对照研究包括从2010年和2016年之间的康复康复病房录取和排放的连续老年患者。参与者根据住院期间的存在或缺乏髋部骨折分割。在组之间分析了人口统计数据，实验室数据和功能独立度量。主要结果是存在髋部骨折。进行了多元逻辑回归分析，以分析抗胆碱能药物使用与髋部骨折之间的关系。结果总共601名参与者（210名男性，391名女性;第73-85岁的四分位数范围）被列入本研究。髋部骨折的多元逻辑回归分析，调整混杂因子，表明抗胆碱能药物用途与髋骨骨折呈正相关。特别是，抗胆碱能程度评分的增加2点与髋部骨折的风险2.86倍，增加≥3分的风险导致风险为4.21倍，均具有统计学上显着的结果。结论住院期间的抗胆碱能载量增加可能是老年患者髋部骨折增加的预测因子。 GeriaTr Gerontol int 2018; 18：1340-1344。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号