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首页> 外文期刊>Gynecological endocrinology: the official journal of the International Society of Gynecological Endocrinology >Potential synergism between ulipristal acetate and vitamin D3 in uterine fibroid pharmacotherapy - 2 case studies
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Potential synergism between ulipristal acetate and vitamin D3 in uterine fibroid pharmacotherapy - 2 case studies

机译：子宫肌瘤药物疗法尿醋酸盐和维生素D3之间的潜在协同作用 - 2例研究

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摘要

This is a preliminary report of the first cases of successful simultaneous use of ulipristal acetate (UPA) and vitamin D3 in uterine fibroid (UF) oral treatment in humans. We present two cases of 37- and 49-year-old females with clinically symptomatic UFs and vitamin D deficiency. Both patients were treated with a standard 3 months of UPA scheme (5 mg daily) with the additional use of vitamin D3 (7000IU daily orally). In the 37-year-old female all the symptoms (pain, pressure, frequent urination) decreased, total tumor volume after the treatment changed by 47.8%. In the 49-year-old female most symptoms perished, total tumor volume was reduced by 63.3%. UPA and vitamin D share synergistic anti-fibroid properties. Further studies are necessary to show the exact effect of UPA and vitamin D as co-drugs.
机译：这是对人类中子宫肌瘤（UF）口服治疗中的第一个成功同时使用尿醋酸脲（UP）和维生素D3的第一个初步报告。 我们在临床上症状UF和维生素D缺乏症中展示了两种37岁和49岁女性的案例。 两种患者都用标准的3个月的UPA方案（每日5毫克）治疗，并额外使用维生素D3（每日7000UU）。 在37岁的女性所有症状（疼痛，压力，频繁排尿）下降，治疗后的总肿瘤体积减少47.8％。 在49岁的女性最具症状中，总肿瘤体积减少了63.3％。 UPA和维生素D股份协同抗纤维菌特性。 进一步的研究是表现出UPA和维生素D作为共同药物的确切效果。

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