• 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Gynecological endocrinology: the official journal of the International Society of Gynecological Endocrinology >Metabolic endotoxaemia - a potential novel link between ovarian inflammation and impaired progesterone production
【24h】

Metabolic endotoxaemia - a potential novel link between ovarian inflammation and impaired progesterone production

机译：代谢内毒性毒性 - 卵巢炎症和黄体酮生产受损之间的潜在新颖联系

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Introduction: Medical conditions such as obesity and inflammatory bowel disease are associated with impaired luteal function, menstrual disturbance and infertility. It is proposed that the disturbance in gut wall integrity ("leaky gut") seen in these conditions may result in the passage of bacterial endotoxin (LPS) from the colonic lumen into the circulation that may initiate inflammation in the ovary and subsequently impair hormone production. Methods: Quantify the association between systemic levels of LBP, a marker of endotoxin exposure, and levels of inflammation in the ovary (follicular fluid IL-6), plus steroid hormone production in 45 women undergoing IVF treatment. Results: Endotoxaemia (LBP) were positively correlated with plasma CRP and inflammation within the ovary (follicular fluid IL-6). Furthermore, endotoxaemia was negatively correlated with progesterone production. Conclusion: The observed correlations, together with previously published animal studies linking endotoxin exposure to impaired luteal function, suggest that the translocation of bacterial endotoxin from the gut lumen into the circulation has the potential to interfere with progesterone production and result in luteal deficiency.
机译：简介：肥胖症和炎症性肠病等医疗条件与患力函数受损，月经干扰和不孕症有关。建议在这些条件下观察到的肠道壁完整性（“泄漏肠道”）的干扰可能导致细菌内毒素（LPS）从结肠内腔中通过，进入卵巢中可能引发卵巢和随后损伤激素生产的血液循环。方法：量化LBP的全身水平之间的关联，内毒素暴露的标志物，卵巢（滤液IL-6）中的炎症水平，加上45例患有IVF治疗的女性肝固醇产量。结果：内卵酸血症（LBP）与卵巢（卵巢液IL-6）的血浆CRP和炎症正相关。此外，内卵肿瘤与孕酮的生产呈负相关。结论：观察到的相关性，与先前公布的动物研究联系在一起将内毒素暴露在损伤障碍障碍中，表明，从肠腔流入循环中的细菌内毒素的易位具有干扰孕酮的产生并导致患力缺乏症。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号