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首页> 外文期刊>Gynecological endocrinology: the official journal of the International Society of Gynecological Endocrinology >Long-term cardiovascular hospitalizations of small for gestational age (SGA) offspring born to women with and without gestational diabetes mellitus (GDM)*
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Long-term cardiovascular hospitalizations of small for gestational age (SGA) offspring born to women with and without gestational diabetes mellitus (GDM)*

机译：长期心血管住院的小于孕龄（SGA）后代出生于患有和没有妊娠糖尿病的女性（GDM）*

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Objective: To assess whether delivery of small for gestational age (SGA) neonates to mothers with gestational diabetes mellitus (GDM) increases the risk of long-term cardiovascular offspring hospitalizations compared to SGA neonates born to mothers without GDM. Study design: This is a population-based retrospective cohort study. The study group was SGA offspring born to mothers with GDM (n = 259), while the control group was SGA offspring born to mothers without GDM (n = 9053). The main factor evaluated was offspring cardiovascular hospitalizations up to the age of 18 years. Kaplan-Meier survival curve was used to estimate cumulative incidence of cardiovascular hospitalizations. A Cox proportional hazards model was used to estimate the adjusted hazard ratios (HR) for cardiovascular hospitalizations. Results: SGA children born to mothers with GDM had significantly higher rates of cardiovascular-related hospitalizations (1.9% vs. 0.7%, p = .026). A Kaplan-Meier survival curve demonstrated that SGA children born to GDM mothers had a higher cumulative incidence of cardiovascular hospitalizations (log-rank p = .037). The Cox regression model, while controlling for confounders, demonstrated that delivery of SGA neonates to mothers with GDM is independently associated with long-term cardiovascular offspring hospitalizations (adjusted HR =2.6; 95% CI 1.02-6.55 p = .045). Conclusion: Delivery of SGA neonates born to mothers with GDM is independently associated with long-term cardiovascular offspring hospitalizations.
机译：目的：评估是否为孕态糖尿病患者（GDM）向母亲的母亲（SGA）新生儿的排放量增加了长期心血管后代住院的风险与没有GDM的母亲出生的SGA新生儿。研究设计：这是一种基于人口的回顾队列队列研究。研究组是SGA后代出生于母亲的母亲（n = 259），而对照组是SGA后代出生于没有GDM的母亲（n = 9053）。评估的主要因素是后代心血管住院，高达18岁。 Kaplan-Meier生存曲线用于估算心血管住院的累积发病率。 COX比例危害模型用于估算心血管住院的调整后危险比（HR）。结果：患有GDM的母亲的SGA儿童显着提高了相关的心血管相关住院率（1.9％vs.0.7％，P = .026）。 Kaplan-Meier生存曲线展示了向GDM母亲出生的SGA儿童具有更高的心血管住院累积率（LOG-RANK P = .037）。 Cox回归模型，同时控制混淆，表明，用GDM的母亲递送SGA新生儿与长期心血管后代住院相关（调整后的HR = 2.6; 95％CI 1.02-6.55 P = .045）。结论：向母亲携带的母亲提供GDM的SGA新生儿与长期心血管后代住院相关。

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