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首页> 外文期刊>Gynecological endocrinology: the official journal of the International Society of Gynecological Endocrinology >Liver function, tolerability and satisfaction during treatment with ulipristal acetate in women with fibroids: a single center experience
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Liver function, tolerability and satisfaction during treatment with ulipristal acetate in women with fibroids: a single center experience

机译：用肌瘤女性尿乙酸尿酸盐治疗肝功能，耐受性和满足感：单一中心经验

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The aim of the study was to evaluate liver function in women treated with ulipristal acetate (UPA) and to assess the tolerability and satisfaction during treatment. This Cross-sectional study included women with symptomatic uterine fibroids subjected to one or more 3-month treatment courses of 5 mg UPA daily. Following European Medical Agency's prescriptions, women were asked about symptoms potentially related to liver damage and had blood tests done, to assess serum levels of aspartate aminotransferase (AST) and alanine aminotransferase (ALT). Data on side effects, tolerability and satisfaction with the therapy were obtained during a phone interview. A total of 162 women completed the study with a mean treatment duration of 1.8 +/- 0.9 cycles. No increased AST and ALT serum levels were detected and no woman reported symptoms suggestive of liver injury. The majority of women reported improvement of fibroids-related symptoms and a high degree of satisfaction with treatment. More than half of women had side effects, in most cases not as severe as to discontinue therapy. Ulipristal acetate did not worsen liver function or cause severe organ injury and showed high tolerability and satisfaction profiles. Therefore, we believe that it can still be considered a valuable option in the treatment of uterine fibroids.
机译：该研究的目的是评估用尿醋酸脲（UPA）治疗的女性的肝功能，并评估治疗过程中的耐受性和满足。这种横断面研究包括患有症状子宫肌瘤的女性，每天每天进行5毫克或多个3个月的治疗课程。欧洲医疗机构的处方后，妇女被问及潜在与肝损伤有关的症状，并进行血液测试，以评估血清水平的天冬氨酸氨基转移酶（AST）和丙氨酸氨基转移酶（ALT）。在电话面试中获得了副作用，耐受性和满足的数据。共有162名女性完成了该研究，平均治疗持续时间为1.8 +/- 0.9周期。未检测到AST和ALT血清水平的增加，没有患者报告症状暗示肝损伤。大多数女性报告了肌瘤相关症状的改善和对治疗的高度满意度。超过一半的女性具有副作用，在大多数情况下，不应该终止治疗。近极醋酸盐没有恶化肝功能或引起严重的器官损伤，并且显示出高耐受性和满足性曲线。因此，我们认为，在治疗子宫肌瘤中仍然可以被认为是一种有价值的选择。

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