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首页> 外文期刊>Gynecological endocrinology: the official journal of the International Society of Gynecological Endocrinology >Dipeptidyl peptidase-4 and adenosine deaminase enzyme levels in polycystic ovary syndrome
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Dipeptidyl peptidase-4 and adenosine deaminase enzyme levels in polycystic ovary syndrome

机译：多囊卵巢综合征中二肽基肽酶-4和腺苷脱氨基酶酶水平

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Polycystic ovary syndrome (PCOS) is one of the most common endocrinopathies in reproductive age women and insulin resistance (IR) and hyperinsulinism play a critical role in the pathogenesis. Glucagon-like peptide-1 (GLP-1), promotes insulin secretion, inhibits glucagon secretion. GLP-1 is degraded by dipeptidyl peptidase-4 (DPP-4). DPP-4, also interacts with adenosine deaminase (ADA). Therefore, IR may have a significant connection with ADA activity. The aim of this study is to compare levels of DPP-4 and ADA enzymes in PCOS and infertile patients. Forty-four patients with PCOS and 44 infertile patients with normal ovarian reserve were enrolled in the study. Serum ADA, DPP-4, AMH, glucose and insulin levels were measured. HOMA-IR method was used to assess insulin sensitivity. ADA, DPP-4, AMH, HOMA-IR (p<.05) and insulin levels (p<.01) were found to be increased in PCOS patients. Considering all study participants AMH levels were found to be positively correlated with ADA {r. 0.734) and DPP-4 (r: 0.449) levels. Also ADA levels were found to be positively correlated with DPP-4 {r. 0.472), insulin (r: 0.216) and HOMA-IR (r: 0.223). Our findings about the elevation of DPP-4 levels in patients with PCOS suggest that the use of DPP-4 inhibitors may be beneficial in treatment of these patients.
机译：多囊卵巢综合征（PCOS）是生殖年龄妇女最常见的内分泌术和胰岛素抵抗（IR）和高胰岛素主义在发病机制中发挥关键作用之一。胰高血糖素肽-1（GLP-1）促进胰岛素分泌，抑制胰高血糖素分泌。通过二肽基肽酶-4（DPP-4）降解GLP-1。 DPP-4，也与腺苷脱氨酶（ADA）相互作用。因此，IR可以与ADA活性进行显着连接。本研究的目的是比较PCOS和不孕症患者的DPP-4和ADA酶的水平。研究中共有四十四名PCOS和44名不孕症患者患者。测量血清ADA，DPP-4，AMH，葡萄糖和胰岛素水平。 HOMA-IR方法用于评估胰岛素敏感性。在PCOS患者中发现ADA，DPP-4，AMH，HOMA-IR（P <.05）和胰岛素水平（p <.01）增加。考虑到所有研究参与者AMH水平被发现与ADA {R相关联。 0.734）和DPP-4（R：0.449）水平。也发现ADA水平与DPP-4 {R呈正相关。 0.472），胰岛素（R：0.216）和HOMA-IR（R：0.223）。我们关于PCO患者DPP-4水平的研究结果表明，使用DPP-4抑制剂的使用可能是有益的治疗这些患者。

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