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首页> 外文期刊>Gynecological endocrinology: the official journal of the International Society of Gynecological Endocrinology >Anti-Mullerian hormone does not predict time to pregnancy: results of a prospective cohort study
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Anti-Mullerian hormone does not predict time to pregnancy: results of a prospective cohort study

机译：抗Mullerian激素无法预测怀孕时间：未来队列研究的结果

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In order to study whether ovarian reserve tests (ORTs) can predict time to ongoing pregnancy, we conducted a prospective cohort study in a cohort of healthy pregnancy planners. A total of 102 pregnancy planners were followed for 1year, or until ongoing pregnancy occurred, after cessation of contraceptives). A baseline measurement of anti-Mullerian hormone (AMH), follicle-stimulating hormone (FSH) and antral follicle count (AFC) was conducted. At the end of follow-up, a semen analysis was performed and chlamydia antibody titres were assessed. A univariate prediction model demonstrated age and the AFC to be significantly capable of predicting time to pregnancy (hazard ratio 0.92, 95% CI 0.87-0.98, p=0.01; 1.04, 95% CI 1.01-1.07, p=0.02 respectively). In the multivariate model, however, correcting for female age, we found no predictive effect of AMH, basal FSH or the AFC for time to ongoing pregnancy (hazard ratios 1.43, 95% CI 0.84-2.46, p=0.36; 0.96, 95% CI 0.86-1.06, p=0.43; 1.03, 95% CI 1.00-1.07, p=0.08, respectively). This was confirmed by the low C-statistic. We therefore concluded that baseline AMH, AFC or FSH levels do not predict time to ongoing pregnancy in a cohort of healthy pregnancy planners. These results limit the usability of these ORTs in the assessment of current fertility.
机译：为了研究卵巢储备测试（ORTS）是否可以预测持续怀孕时​​间，我们在健康妊娠策划队列队列中进行了一项潜在的队列研究。在停止避孕药时，共有102名怀孕策划者，或直到发生在持续的怀孕之前）。进行了抗Mullerian激素（AMH），卵泡刺激激素（FSH）和Antral卵泡计数（AFC）的基线测量。在随访结束时，进行了精液分析，评估衣原体抗体滴度。一个单变量预测模型表现出年龄和AFC，显着能够预测妊娠时间（危险比0.92,95％CI 0.87-0.98，P = 0.01; 1.04,95％CI 1.01-1.07，P = 0.02）。然而，在多变量模型中，纠正女性年龄，我们发现没有AMH，基础FSH或AFC的预测效果，持续妊娠（危险比1.43,95％CI 0.84-2.46，P = 0.36; 0.96,95％ CI 0.86-1.06，P = 0.43; 1.03,95％CI 1.00-1.07，P = 0.08分别）。这是由低C统计学证实的。因此，我们得出结论，基准AMH，AFC或FSH水平并未预测健康妊娠兰纳队队列的持续怀孕时​​间。这些结果限制了这些ORTS在当前生育率的评估中的可用性。

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