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首页> 外文期刊>Gynecological endocrinology: the official journal of the International Society of Gynecological Endocrinology >Assessment of ovarian reserve as an indicator of fertility and health consequences in patients with chronic kidney disease stages 3-4
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Assessment of ovarian reserve as an indicator of fertility and health consequences in patients with chronic kidney disease stages 3-4

机译：卵巢储备评为慢性肾病阶段患者生育和健康后果的指标3-4

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The aim of the study was to evaluate whether ovarian reserve depends on chronic kidney disease. Twenty-four patients, 23-45 years with chronic kidney disease (CKD) stages 3-4 were included in the study. All the patients underwent transvaginal ultrasounds to assess antral follicle count (AFC) and ovarian volume. The serum samples were obtained on days 3-5 of the menstrual cycle from all participants for anti-Mullerian hormone (AMH), follicle stimulating hormone (FSH), and estradiol (E2) levels. On the base of the study, it was concluded that the most sensitive parameters of ovarian reserve are AMH and AFC. AMH levels and number of antral follicles in both ovaries were statistically significantly lower in the group of patients with CKD than in control ones. But there were no significant differences in the ovarian volumes (right and left ovary), FSH and E2 levels between study and control groups. Ovarian reserve is not dependent on the duration of CKD and hormonal parameters of ovarian reserve like FSH and estradiol (E2) are not dependent on the presence or absence of proteinuria in patients with CKD, but the most sensitive parameter - AMH is significantly lower in patients with CKD and proteinuria.
机译：该研究的目的是评估卵巢储备是否取决于慢性肾病。二十四名患者，23-45岁患有慢性肾病（CKD）阶段3-4阶段。所有患者都接受了经过传递的超声，评估嗜睡卵泡计数（AFC）和卵巢体积。从抗Mullerian激素（AMH），卵泡刺激激素（FSH）和雌二醇（E2）水平的所有参与者的月经周期的日期3-5天中获得血清样品。在研究的基础上，得出结论，卵巢储备最敏感的参数是AMH和AFC。在CKD的患者中，卵巢中的AMH水平和卵巢卵泡的数量比对照组患者统计学显着降低。但研究和对照组之间的卵巢体积（左右卵巢），FSH和E2水平没有显着差异。卵巢储备不依赖于CKD的持续时间，如FSH和雌二醇（E2）的卵巢储备的荷尔蒙参数不依赖于CKD患者的蛋白尿存在或不存在，但患者中最敏感的参数 - AMH显着降低用CKD和蛋白尿。

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