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首页> 外文期刊>Gynecological endocrinology: the official journal of the International Society of Gynecological Endocrinology >Systematic review and meta-analysis of Spanish studies regarding the association between maternal 25-hydroxyvitamin D levels and perinatal outcomes
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Systematic review and meta-analysis of Spanish studies regarding the association between maternal 25-hydroxyvitamin D levels and perinatal outcomes

机译：西班牙语研究的系统评价与荟萃分析关于母体25-羟基乙多素D水平和围产期结果的关联

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Objective: This systematic review and meta-analysis of Spanish studies assessed the association of maternal 25-hydroxyvitamin D [25(OH)D] levels on perinatal outcomes. Methods: PubMed, Cochrane Library, Embase, Scielo, Scopus, and Web of Science research databases were searched from inception through December 30 2017 using the terms 'vitamin D', 'pregnancy', and 'Spain'. Studies that compared first or second half of pregnancy normal 25(OH)D (>30.0ng/mL) versus insufficient (20.0-29.9 ng/mL) or deficient (<20.0ng/mL) circulating levels and perinatal outcomes were systematically extracted. Data are presented as pooled odds ratios and their 95% confidence intervals (CIs) for categorical variables or mean differences and CIs for continuous variables. Risk of bias was evaluated with the Newcastle-Ottawa Scale. Results: Five cohort studies met inclusion criteria. The risk of gestational diabetes mellitus, preeclampsia, preterm birth, and small-for-gestational-age infants, and birthweight was not influenced by first half of pregnancy maternal 25(OH)D levels. In addition, second half of pregnancy 25(OH) levels did not affect birthweight. Conclusion: Maternal 25(OH)D levels during pregnancy did not affect studied perinatal outcomes and birthweight.
机译：目的：这种系统审查和荟萃分析西班牙语研究评估了母体25-羟基维胺D [25（OH）D]水平对围产期结果的关联。方法：从2017年12月30日期，从2017年12月30日使用条款“维生素D”，“怀孕”和“西班牙”，搜索了PubMed，Cochrane图书馆，Embase，Scielo，Scopus和科学研究数据库网络。在系统提取系统地提取了对妊娠第一个或第二半（OH）D（> 30.0ng / ml）而不足（20.0-29.9ng / ml）或缺陷（<20.0ng / ml）和围产后的研究的研究。数据作为汇集的赔率比和它们的95％置信区间（CIS），用于分类变量或连续变量的平均差异和CIS。使用纽卡斯尔 - 渥太华规模评估偏见的风险。结果：五项队列研究符合纳入标准。妊娠期糖尿病的风险，先兆子痫，早产和小于胎龄的婴儿，出生重量不受怀孕母体25（OH）D级别的前半部分。此外，怀孕的下半部分25（OH）水平不影响出生体重。结论：怀孕期间的母体25（OH）D水平并未影响围产期结果和出生重量。

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