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首页> 外文期刊>Forensic science international >Optimization of cloned enzyme donor immunoassay cut-offs for drugs of abuse in whole blood of drivers involved in road accidents
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Optimization of cloned enzyme donor immunoassay cut-offs for drugs of abuse in whole blood of drivers involved in road accidents

机译:优化克隆酶供体免疫测定削减,涉及道路事故司机全血药物的滥用药物

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Introduction: Immunoassay (IA) tests should be able to detect low concentrations of illegal drugs when used for the screening of drugs in drivers. False negatives should be avoided, and false positives should be reduced as far as possible. In this study, semi-quantitative results for blood samples containing illicit drugs (cannabinoids, cocaine, amphetamines/methamphetamines, opiates and methadone) obtained with cloned enzyme donor immunoassay (CEDIA), were compared with results of confirmatory analysis performed through gas chromatography-mass spectrometry (GC-MS). Screening cut-off points for each class of drugs were retrospectively optimized.
机译:简介:免疫测定(IA)试验应能够在用于筛选司机中的药物时检测低浓度的非法药物。 应该避免伪造的否定,并且应尽可能减少误报。 在本研究中,将含有非法药物的血液样品(大麻素,可卡因,甲基苯丙胺/甲基苯丙胺,阿片类药物和美沙酮)的半定量结果与通过气相色谱 - 质量进行的确认分析结果进行比较 光谱法(GC-MS)。 回顾性优化每类药物的筛选点切断点。

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