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首页> 外文期刊>Fish & Shellfish Immunology >Immunohistochemical examination of immune cells in adipose tissue of rainbow trout (Oncorhynchus mykiss) following intraperitoneal vaccination
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Immunohistochemical examination of immune cells in adipose tissue of rainbow trout (Oncorhynchus mykiss) following intraperitoneal vaccination

机译：腹腔疫苗接种后虹鳟鱼脂肪组织免疫细胞免疫细胞免疫细胞检查

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Mammalian perivisceral adipose has been shown to play an important role in the regulation of the peritoneal immune responses. Recently it has been demonstrated that peritoneal antigens are collected by leukocytes within the visceral adipose mass, and a broad range of immunomodulatory genes are differentially expressed in adipose tissue after intraperitoneal vaccination in rainbow trout. To assess the immune cell component in adipose, immunohistochemical analysis was used to examine B-cell, T-cell and antigen presenting cell (APC) numbers and distribution in rainbow trout adipose tissue 24 and 72 h post vaccination in comparison to control fish. The results of this study support previous work on mammals with omental milky spots in naive fish found to contain APCs and T-cells which then increased in size, number and complexity following vaccination. It suggests that following peritoneal stimulation the visceral adipose mass in fish likely plays an important role in vaccine antigen uptake and presentation by APCs, as well as subsequent T-cell activation and differentiation.
机译：哺乳动物隐喻脂肪已被证明在腹膜免疫应答的调节中发挥着重要作用。最近已经证明，腹膜内脂肪物质内的白细胞收集腹膜抗原，并且在虹膜鳟鱼中腹膜内接种后，在脂肪组织中差异地表达了广泛的免疫调节基因。为了评估脂肪的免疫细胞组分，使用免疫组化分析来检查B细胞，T细胞和抗原呈递细胞（APC）数量和虹鳟鱼脂肪组织24和72h接种后的疫苗接种的分布。本研究的结果支持以前的哺乳动物在野生鱼中含有Omental Milky斑点，发现含有APC和T细胞，随后疫苗接种后的大小，数量和复杂性增加。它表明，在腹膜刺激之后，鱼中的内脏脂肪肿块可能在疫苗抗原吸收和呈递中发挥重要作用，以及随后的T细胞活化和分化。

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