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Effects of opioids on the parental brain in health and disease

机译:阿片类药物对健康疾病父母的影响

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摘要

The epidemic of opioid use disorder (OUD) directly affects millions of women of child-bearing age. Unfortunately, parenting behaviors - among the most important processes for human survival are vulnerable to the effects of OUD. The standard of care for pregnant women with OUD is opioid maintenance therapy (OMT), of which the primary objective is to mitigate addiction-related stress. The aim of this review is to synthesize current information specific to pregnancy and parenting that may be affected by OUD. We first summarize a model of the parental brain supported by animal research and human neuroimaging. We then review animal models of exogenous opioid effects on parental brain and behavior. We also present preliminary data for a unifying hypothesis that may link different effects of exogenous opioids on parenting across species and in the context of OMT. Finally, we discuss future directions that may inform research and clinical decision making for peripartum women with OUD.
机译:阿片类药物的流行病(Oud)直接影响数百万妇女的宿户年龄。 不幸的是,育儿行为 - 人类生存最重要的过程中易受oud的影响。 具有oud的孕妇的护理标准是阿片类药物维护治疗(OMT),其中主要目标是减轻与上瘾相关的压力。 本综述的目的是综合可能受OUD影响的怀孕和育儿特定的当前信息。 我们首先总结了动物研究和人类神经影像的父母脑的模型。 然后,我们评论对父母大脑和行为的外源阿片类药物的动物模型。 我们还提出了初步数据,以便统一假设,可将外源阿片类药物对患有物种的育儿和OMT的背景联系起来的不同影响。 最后,我们讨论了未来的方向,可能会通知围龄妇女的研究和临床决策。

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