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首页> 外文期刊>Frontiers in neuroendocrinology >Sugar in mind: Untangling a sweet and sour relationship beyond type 2 diabetes
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Sugar in mind: Untangling a sweet and sour relationship beyond type 2 diabetes

机译：考虑到糖：超越2型糖尿病的甜味和酸性关系

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It is widely recognised that type 2 diabetes (T2D) represents a major disease burden but it is only recently that its role in neurodegeneration has attracted more attention. This research has shown that T2D is associated with impaired cerebral health, cognitive decline and dementia. However, the impact on the brain of progressive metabolic changes associated with the pre-clinical development of the disease is less clear. The aim of this review is to comprehensively summarise how the emergence of risk factors and co-morbid conditions linked to the development of T2D impact cerebral health. Particular attention is directed at characterising how normal but elevated blood glucose levels in individuals without T2D contribute to neurodegenerative processes, and how the main risk factors for T2D including obesity, physical activity and diet modulate these effects. Where available, evidence from the animal and human literature is contrasted, and sex differences in risk and outcomes are highlighted.
机译：众所周知，2型糖尿病（T2D）代表着一种主要的疾病负担，但最近它才能在神经变性中的作用引起了更多的关注。该研究表明，T2D与脑健康，认知下降和痴呆有损。然而，与临床前疾病前临床开发相关的渐进式代谢变化的脑部的影响较小。本综述的目的是全面地总结如何出现风险因素和与T2D影响脑健康发展的开发相关的危险因素。特别注意的是表征个体中血糖水平的正常但升高的血糖水平有助于神经变性过程，以及T2D包括肥胖，身体活动和饮食的主要风险因素如何调节这些效果。在可用的情况下，来自动物和人类文学的证据形成鲜明对比，并且突出了风险和结果的性别差异。

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