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首页> 外文期刊>Frontiers in neuroendocrinology >Neuroimaging premenstrual dysphoric disorder: A systematic and critical review
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Neuroimaging premenstrual dysphoric disorder: A systematic and critical review

机译：神经影像经常性疑惑障碍：系统和批评

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摘要

Endocrine organizational and activational influences on cognitive and affective circuits are likely critical to the development of premenstrual dysphoric disorder (PMDD), a sex-specific hormone-dependent mood disorder. An overview of the anatomical and functional neural characterization of this disorder is presented here by means of neuroimaging correlates, identified from eighteen publications (n = 361 subjects). While white matter integrity remains uninvestigated, greater cerebellar grey matter volume and metabolism were observed in patients with PMDD, along with altered serotonergic and GABAergic neurotransmission. Differential corticolimbic activation in response to emotional stimuli distinguishes the PMDD brain, namely enhanced amygdalar and diminished fronto-cortical function. Thus far, the emotional distress and dysregulation linked to PMDD seem to be defined by structural, chemical and functional brain signatures; however, their characterization remains sparsely studied and somewhat inconsistent. Clear and well-replicated neurobiological features of PMDD are needed to promote timely diagnoses and inform development of prevention and treatment strategies.
机译：对认知和情感电路的内分泌组织和激活影响可能对经前期烦躁症（PMDD）的发展，性别特异性激素依赖性情绪障碍至关重要。通过神经模仿相关性，从18个出版物（n = 361个受试者）鉴定出该病症的解剖学和功能神经特征的概述。虽然白质完整性仍然是未异常的，但在PMDD患者中观察到更大的小脑灰质体积和代谢，以及改变的血清onoleric和胃肠杆菌神经递质。鉴别型皮质醇激活响应情绪刺激，区分PMDD脑，即增强的Amygdalar和尺寸的前皮疹功能。到目前为止，与PMDD相关的情绪困扰和失呼似乎由结构，化学和功能性脑签名定义;然而，他们的表征仍然稀疏地研究，有点不一致。需要清晰且良好的PMDD的神经生物学特征需要及时诊断，并提供预防和治疗策略的发展。

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