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首页> 外文期刊>Fungal Biology Reviews >Role of Candida albicans mating in genetic variability and adaptation to the host
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Role of Candida albicans mating in genetic variability and adaptation to the host

机译：Candida albicans在遗传变异和适应宿主的作用

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摘要

Since its discovery at the end of the XIX century, Candida albicans has emerged as one of the most important human pathogenic fungi. This yeast efficiently colonizes the gastrointestinal cavity of humans, which is an important source for gastrointestinal-mediated dissemination of the fungus to internal organs under immune suppression. Controlling colonization may therefore lead to the eradication of C. albicans which may, in turn, be a useful strategy in the prevention of candidiasis. Recent studies indicate that colonization is influenced by -and related to-the white opaque (wo) transition, an epigenetic transition that has been shown to mediate several aspects of the biology of this fungus. Efficient mating in C. albicans occurs by a two-step process which involves the conversion to a homozygous mating type cell followed by a transition to the opaque state. The discovery of the opaque cell as the mating competent phase of this fungus provided an interesting evolutionary example of the role of mating in the adaptation to a mammalian host in a pathogenic fungus. A full sexual cycle has not been observed; rather, after mating, return to a diploid state is achieved by concerted chromosome loss, being this an important source of genetic variability for this opportunistic pathogen. (C) 2019 Published by Elsevier Ltd on behalf of British Mycological Society.
机译：自从XIX世纪末发现以来，念珠菌白葡萄酒已成为最重要的人类致病真菌之一。该酵母有效地殖民殖民解的人类胃肠腔，这是免疫抑制下内脏胃肠道介导的真菌介导的重要来源。因此，控制定植可能导致消除可能反过来可能导致的C.醛型人为预防念珠菌病的一种有用策略。最近的研究表明，殖民化受到与白差（WO）过渡相关的和相关的，表观甲型过渡，已经显示出介导该真菌生物学的若干方面。在C. albicans中的高效交配通过两步过程发生，其涉及转化为纯合配合型电池，然后转换为不透明状态。作为该真菌的交配态阶段的不透明细胞的发现提供了一种有趣的进化示例，其在致病真菌中适应哺乳动物宿主的作用。尚未观察到完整的性循环;相反，在交配后，通过协调染色体损失来恢复二倍体状态，这是这种机会理性病原体的遗传变异性的重要来源。 （c）2019年由elsevier有限公司发布代表英国Mycological社会。

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  • 来源
    《Fungal Biology Reviews》 |2019年第4期|共10页
  • 作者

    Correia Ines; Roman Elvira; Priet Daniel; Hidalgo-Vic Susana; Alonso-Monge Rebeca; Pla Jesus;

  • 作者单位

    I3S IBMC Biomol Struct &

    Funct Grp Rua Alfredo Allen 208 P-4200135 Porto Portugal;

    Univ Complutense Madrid Fac Farm Dept Microbiol &

    Parasitol IRYCIS Plaza Ramon Y Cajal S-N E-28040 Madrid Spain;

    Univ Complutense Madrid Fac Farm Dept Microbiol &

    Parasitol IRYCIS Plaza Ramon Y Cajal S-N E-28040 Madrid Spain;

    Univ Complutense Madrid Fac Farm Dept Microbiol &

    Parasitol IRYCIS Plaza Ramon Y Cajal S-N E-28040 Madrid Spain;

    Univ Complutense Madrid Fac Farm Dept Microbiol &

    Parasitol IRYCIS Plaza Ramon Y Cajal S-N E-28040 Madrid Spain;

    Univ Complutense Madrid Fac Farm Dept Microbiol &

    Parasitol IRYCIS Plaza Ramon Y Cajal S-N E-28040 Madrid Spain;

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  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类 免疫学;
  • 关键词

    Candida albicans; Epigenetic; Mating; Morphogenesis; Variability; White opaque;

    机译：念珠菌蛋白;表观遗传;交配;形态发生;变异性;白色不透明;

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