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首页> 外文期刊>ACS Synthetic Biology >Intelligent Microbial Heat-Regulating Engine (IMHeRE) for Improved Thermo-Robustness and Efficiency of Bioconversion
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Intelligent Microbial Heat-Regulating Engine (IMHeRE) for Improved Thermo-Robustness and Efficiency of Bioconversion

机译：智能微生物调温引擎（IMHeRE）可提高热稳定性和生物转化效率

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摘要

The growth and production of microorganisms in bioconversion are often hampered by heat stress. In this study, an intelligent microbial heat-regulating engine (IMHeRE) was developed and customized to improve the thermo-robustness of Escherichia coli via the integration of a thermotolerant system and a quorum-regulating system. At the cell level, the thermotolerant system composed of different heat shock proteins and RNA thermometers hierarchically expands the optimum temperature by sensing heat changes. At the community level, the quorum-regulating system dynamically programs the altruistic sacrifice of individuals to reduce metabolic heat release by sensing the temperature and cell density. Using this hierarchical, dynamical, and multilevel regulation, the IMHeRE is able to significantly improve cell growth and production. In a real application, the production of lysine was increased 5-fold at 40 degrees C using the IMHeRE. Our work provides new potential for the development of bioconversion by conserving energy and increasing productivity.
机译：生物转化中微生物的生长和产生通常受到热胁迫的阻碍。在这项研究中，开发并定制了智能微生物热调节引擎（IMHeRE），以通过将耐热系统和定额调节系统集成来提高大肠杆菌的热稳定性。在细胞水平上，由不同的热激蛋白和RNA温度计组成的耐热系统通过感测热变化来逐步扩展最佳温度。在社区一级，法定人数调节系统动态地编程个人的无私牺牲，以通过感测温度和细胞密度来减少代谢热释放。使用这种分级，动态和多级调节，IMHeRE能够显着改善细胞生长和产量。在实际应用中，使用IMHeRE在40摄氏度下赖氨酸的产量增加了5倍。我们的工作通过节约能源和提高生产力为生物转化的发展提供了新的潜力。

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