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Vitreous Analysis in the Management of Uveitis

机译:葡萄膜炎管理的玻璃体分析

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摘要

A correct diagnosis of uveitis is often challenging, given the wide range of possible underlying conditions and the lack of typical phenotypes. Management decisions may be difficult in view of the risk of visual loss with either inappropriate or delayed therapy. Analysis of the vitreous may therefore be used to provide the clinician with valuable information. In this paper, we describe the main clinical situations in which vitreous sampling is indicated and provide some guidance to clinicians for tailoring their requests. These situations include suspected intraocular infection and suspected intraocular malignancy. We describe the principal tests carried out on vitreous samples, including cultures, polymerase chain reaction-based testing, and cytokine analysis. Limitations of the tests used are likely to become less as more advanced testing methods are introduced. The importance of selecting the appropriate investigations to support a clinical suspicion is emphasised, as is the interpretation of test results within a clinical context.
机译:鉴于各种可能的潜在条件和缺乏典型的表型,鉴于各种可能的潜在条件以及缺乏典型表型,对葡萄炎的正确诊断往往是具有挑战性的。鉴于视力丧失的风险,可能是延迟治疗的视觉丧失的风险可能是困难的。因此,可以使用玻璃体的分析来为临床医生提供有价值的信息。在本文中,我们描述了玻璃体采样的主要临床情况,并为临床医生提供一些指导,以定制他们的要求。这些情况包括疑似眼内感染和可疑的眼内恶性肿瘤。我们描述了在玻璃体样本上进行的主要试验,包括培养物,聚合酶链基于基于反应的测试和细胞因子分析。所使用的测试的局限性可能变得越来越少,因为介绍了更先进的测试方法。强调,选择适当调查以支持临床怀疑的重要性,因为在临床环境中对测试结果的解释是对测试结果的解释。

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