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首页> 外文期刊>BJU international >Toxicity following high-dose salvage radiotherapy after radical prostatectomy.
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Toxicity following high-dose salvage radiotherapy after radical prostatectomy.

机译：前列腺癌根治术后大剂量抢救放疗后的毒性。

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OBJECTIVE: To assess gastrointestinal (GI) and genitourinary (GU) toxicity in patients treated with salvage radiotherapy (SRT) at doses of 70.2 Gy after radical retropubic prostatectomy (RRP). PATIENTS AND METHODS: Medical records were reviewed retrospectively to identify patients treated with SRT after RRP between January 1999 and December 2005. Of the 62 patients identified, 30 were included for analysis. GI and GU toxicity was assessed using the National Cancer Institute Common Terminology Criteria for Adverse Events and the American Urological Association Symptom Index (AUASI), respectively. RESULTS: The median AUASI score of the 17 patients with scores before SRT was 4, of the 24 with scores after SRT was 6, and of the 15 with scores before and after SRT the median increase was 3. Of the 29 patients with GI toxicity data, nine (31%) had diarrhoea after SRT (three after <70.2 Gy and six after 70.2 Gy). In all cases, the diarrhoea was mild (grade 1). Of all patients, 12 (41%) had proctitis after SRT(four after <70.2 Gy and eight after 70.2 Gy); the proctitis was grade 1 in four and grade 2 in eight, with no cases of grade 3 proctitis. There was no statistically significant difference in the median change in AUASI scores and GI toxicity incidence between patients receiving <70.2 or 70.2 Gy of SRT. CONCLUSION: High-dose SRT (70.2 Gy) is generally well tolerated with acceptable low-grade GI toxicity and minimal changes in AUASI scores.
机译：目的：评估根治性耻骨后前列腺切除术（RRP）后接受抢救放疗（SRT）70.2 Gy剂量的患者的胃肠道（GI）和泌尿生殖道（GU）毒性。病人和方法：回顾性分析病历，以鉴定在1999年1月至2005年12月间接受RRP后接受SRT治疗的患者。在确定的62例患者中，包括30例进行分析。 GI和GU毒性分别使用美国国家癌症研究所不良事件通用术语标准和美国泌尿科协会症状指数（AUASI）进行评估。结果：SRT前评分的17例患者的AUASI评分中位数为4，SRT后评分为24的24例患者中，SRT前后评分为15的患者中位数增加为3。在29例GI毒性患者中数据显示，SRT后有9人（31％）腹泻（<70.2 Gy后3人，70.2 Gy后6人）。在所有情况下，腹泻都是轻度的（1级）。在所有患者中，有12例（41％）在SRT后患有直肠炎（<70.2 Gy后有4例，在70.2 Gy后有8例）;直肠炎为四分之一等级，八分之二等级，无3级直肠炎病例。在接受<70.2 Gy或70.2 Gy SRT的患者之间，AUASI评分和胃肠道毒性发生率的中位数变化无统计学差异。结论：大剂量SRT（70.2 Gy）通常具有良好的耐受性，可接受的低度GI毒性和AUASI得分的变化很小。

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