Molecular structures of antiviral agents, 2,3-dihydroxybenzaldehyde 2,4-dinitrophenylhydrazone and 4-[(4-methylpiperazin-1-yl)imino]methyl-1,2-benzodiol

Gurskaya GV; Zavodnik VE; Zhukhlistova NE; Kozlov MV

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Molecular structures of antiviral agents, 2,3-dihydroxybenzaldehyde 2,4-dinitrophenylhydrazone and 4-[(4-methylpiperazin-1-yl)imino]methyl-1,2-benzodiol

机译：抗病毒剂2,3,2-二羟基苯甲醛2,4-二硝基苯hydr和4-[（（4-甲基哌嗪-1-基）亚氨基]甲基-1,2-苯并二醇

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摘要

Two antiviral agents, namely, 2,3-dihydroxybenzaldehyde 2,4-dinitrophenylhydrazone and 4-[(4-methylpiperazin-1-yl)imino]methyl-1,2-benzodiol, are studied by X-ray diffraction. The stereochemical features of the molecular structures of the compounds under investigation are discussed, and the possible correlation between the structure and biological activity with respect to hepatitis C virus RNA-dependent RNA polymerase is analyzed.

机译：通过X射线衍射研究了两种抗病毒剂，即2，3-二羟基苯甲醛2，4-二硝基苯hydr和4-[（（4-甲基哌嗪-1-基）亚氨基]甲基-1，2-苯并二醇。讨论了所研究化合物分子结构的立体化学特征，并分析了与丙型肝炎病毒RNA依赖性RNA聚合酶有关的结构与生物学活性之间的可能相关性。

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来源
《Crystallography reports》 |2008年第4期|共5页
作者
Gurskaya GV; Zavodnik VE; Zhukhlistova NE; Kozlov MV;
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正文语种 eng
中图分类晶体学;
关键词
DEPENDENT RNA-POLYMERASE; X-RAY-DIFFRACTION; 1; 2; 3; 4-TETRAHYDROPYRIMIDIN-2-ONES(THIONES); INHIBITION;

机译：依赖的RNA聚合酶;X射线衍射;1;2;3;4-四氢吡啶并酮-2-酮（硫酮）;抑制作用;

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1. Molecular structures of antiviral agents, 2,3-dihydroxybenzaldehyde 2,4-dinitrophenylhydrazone and 4-[(4-methylpiperazin-1-yl)imino]methyl-1,2-benzodiol [J] . Gurskaya GV, Zavodnik VE, Zhukhlistova NE, Crystallography reports . 2008,第4期

机译：抗病毒剂2,3,2-二羟基苯甲醛2,4-二硝基苯hydr和4-[（（4-甲基哌嗪-1-基）亚氨基]甲基-1,2-苯并二醇
2. Synthesis and Biological Evaluation of a Series of 4-(arylamido/imidoalkyl)- 5-(arylideno- 4-oxo-2-thio-imidazolidinyl)-N-(methyl-phenyl-imino) Acridinium Iodides as Potential Antiviral Agents [J] . Abha Bishnoi Rashmi Saxena Suruchi Singh Archna Rani M. N. Joshi S. K. Bajpai Letters in Drug Design & Discovery . 2009,第4期

机译：一系列4-（芳基/亚氨基烷基）-5-（芳基-4-氧代-2-硫代-咪唑啉基）-N-（甲基-苯基-亚氨基）A啶碘化物作为潜在抗病毒剂的合成及生物评价
3. SYNTHESIS OF PYRROLO[2,3-d]PYRIMIDINE ANALOGUES OF THE POTENT ANTITUMOR AGENT N-{4-[3-(2,4-DIAMINO-7H-PYRROLO-[2,3-d]PYRIMIDIN-5-YL)PROPYL]BENZOYL}-L-GLUTAMIC ACID(TNP-351) [J] . Gaojun Zhu, Zenglu Liu, Yun Xu Heterocycles: An International Journal for Reviews and Communications in Heterocyclic Chemistry . 2008,第7期

机译：潜在反作用剂N- {4- [3-（2-，3-DIAMINO-7H-PYROROLO- [2,3-d] PYRIMIDIN-5-YL）丙基的吡咯并[2,3-d]嘧啶类似物的合成]苯甲酰} -L-谷氨酸（TNP-351）
4. Molecular Structures, Rotational Barriers, and Density Functional Theory Studies on 3,5-Diamino-6-(2,3-Dichlorophenyl)-1,2,4-Triazine [C] . Pek-Lan Toh, Suh-Miin Wang International Conference on Computational Science and Engineering . 2019

机译：分子结构，旋转屏障和密度泛函理论研究3,5-二氨基-6-（2,3-二氯苯基）-1,2,4-三嗪
5. Anti-parasitic and anti-bacterial agents: Studies on 1,4-dihydropyridines and 2,4- diaminoquinazolines [D] . Van Horn, Kurt Steven 2013

机译：抗寄生虫和抗菌剂：1,4-二氢吡啶和2,4-二氨基喹唑啉的研究
6. Crystal structures of 4-{(E)-3-(imino-λ5-azanylidene)aminoprop-1-enyl}-NN-dimethylimidazole-1-sulfonamide and 2-(imino-λ5-azanylidene)amino-4-{(E)-3-(imino-λ5-azanylidene)aminoprop-1-enyl}-NN-dimethylimidazole-1-sulfonamide [O] . Lorenzo M. Cruz, Raakiyah Y. Moore, Marcela Torres Gutierrez, 2019

机译：4-{（E）-3-（亚氨基-λ5-氮杂亚基）氨基丙-1-基} -NN-二甲基咪唑-1-磺酰胺和2-（亚氨基-λ5-氮杂亚基）氨基的晶体结构 -4-{（E）-3-（亚氨基-λ5-氮杂亚烷基）氨基丙-1-烯基} -NN-二甲基咪唑-1-磺酰胺
7. Crystal structures of three 1-oxo-1,2-dihydronaphthalene derivatives: dimethyl 4-(4-methoxyphenyl)-2-(4-methylphenyl)-1-oxo-1,2-dihydronaphthalene-2,3-dicarboxylate, dimethyl 1-oxo-2-(pyren-4-yl)-4-(thiophen-2-yl)-1,2-dihydronaphthalene-2,3-dicarboxylate and ethyl 1-oxo-2-phenyl-2,4-bis(thiophen-2-yl)-1,2-dihydronaphthalene-3-carboxylate [O] . S. Gopinath, P. Narayanan, K. Sethusankar, 2017

机译：三种1-氧代-1,2-二氢萘衍生物的晶体结构：4-（4-甲氧基苯基）-2-（4-甲基苯基）-1-氧代-1,2-二氢萘-2,3-二甲酸二甲酯，二甲基1 -oxo-2-（吡喃-4-基）-4-（噻吩-2-基）-1,2-二氢萘-2,3-二羧酸酯和1-氧代-2-苯基-2,4-双（噻吩-2-基）-1,2-二氢萘-3-羧酸乙酯

Molecular structures of antiviral agents, 2,3-dihydroxybenzaldehyde 2,4-dinitrophenylhydrazone and 4-[(4-methylpiperazin-1-yl)imino]methyl-1,2-benzodiol

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