Effect of torpor on host transcriptomic responses to a fungal pathogen in hibernating bats

Field Kenneth A.; Sewall Brent J.; Prokkola Jenni M.; Turner Gregory G.; Gagnon Marianne F.; Lilley Thomas M.; Paul White J.; Johnson Joseph S.; Hauer Christopher L.; Reeder DeeAnn M.

摘要

Abstract > Hibernation, the use of prolonged torpor to depress metabolism, is employed by mammals to conserve resources during extended periods of extreme temperatures and/or resource limitation. Mammalian hibernators arouse to euthermy periodically during torpor for reasons that are not well understood, and these arousals may facilitate immune processes. To determine whether arousals enable host responses to pathogens, we used dual <fc>RNA</fc> ‐Seq and a paired sampling approach to examine gene expression in a hibernating bat, the little brown myotis ( Myotis lucifugus ). During torpor, transcript levels differed in only a few genes between uninfected wing tissue and adjacent tissue infected with Pseudogymnoascus destructans , the fungal pathogen that causes white‐nose syndrome. Within 70–80?min after emergence from torpor, large changes in gene expression were observed due to local infection, particularly in genes involved in pro‐inflammatory host responses to fungal pathogens, but also in many genes involved in immune responses and metabolism. These results support the hypothesis that torpor is a period of relative immune dormancy and arousals allow for local immune responses in infected tissues during hibernation. Host–pathogen interactions were also found to regulate gene expression in the pathogen differently depending on the torpor state of the host. Hibernating species must balance the benefits of energy and water conservation achieved during torpor with the costs of decreased immune competence. Interbout arousals allow hibernators to optimize these, and other, trade‐offs during prolonged hibernation by enabling host responses to pathogens within brief, periodic episodes of euthermy. </abstract> </span> <span class="z_kbtn z_kbtnclass hoverxs" style="display: none;">展开▼</span> </div> <div class="translation abstracttxt"> <span class="zhankaihshouqi fivelineshidden" id="abstract"> <span>机译：</span><Abstract XMLNS =“http://www.wiley.com/namespaces/wiley”type =“main”xml：id =“mec14827-abs-abs-0001”xml：lang =“en”> <title type =“main” >摘要</标题> >冬眠，使用长时间的扭力抑制代谢，被哺乳动物使用哺乳动物在延长的极端温度和/或资源限制期间保存资源。哺乳动物冬二眠机定期在Torpor期间唤起埃德尔米，因为尚未充分理解，这些唤醒人员可以促进免疫过程。为了确定唤醒是否能够对病原体的宿主反应，我们使用双重<Fc> RNA </ Fc> -seq和配对的抽样方法来检查冬眠蝙蝠中的基因表达，小棕色肌球虫（肌肉荧光蛋饼</ i >）。在Torper期间，转录水平仅在未感染的翼组织和感染的邻近组织之间的少数基因差异不同，感染假致ymoocnoocooca stoructans，这是导致白鼻综合征的真菌病原体。在从托麦特出现后70-80中，由于局部感染，观察到基因表达的大变化，特别是在涉及对真菌病原体的促炎宿主反应的基因中，还在许多参与免疫应答和代谢的基因中。这些结果支持Torpor是一个相对免疫休眠和唤醒期间冬眠期间受感染组织的局部免疫应答的假设。还发现宿主病原体相互作用以根据主体的扭力状态调节病原体中的基因表达。冬眠物种必须平衡Torpor期间在Torper期间实现的能量和水资源的好处，免疫能力降低。间隔唤醒允许冬眠者通过在简要介绍内部的埃德赫利的定期发作内容的病原体的持续响应期间优化这些，以及其他权衡的折磨。 </ p> </ abstract> </span> <span class="z_kbtn z_kbtnclass hoverxs" style="display: none;">展开▼</span> </div> </div> <div class="record"> <h2 class="all_title" id="enpatent33" >著录项</h2> <ul> <li> <span class="lefttit">来源</span> <div style="width: 86%;vertical-align: text-top;display: inline-block;"> <a href='/journal-foreign-25253/'>《Molecular ecology》</a> <b style="margin: 0 2px;">|</b><span>2018年第18期</span><b style="margin: 0 2px;">|</b><span>共17页</span> </div> </li> <li> <div class="author"> <span class="lefttit">作者</span> <p id="fAuthorthree" class="threelineshidden zhankaihshouqi"> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Field Kenneth A.&option=202" target="_blank" rel="nofollow">Field Kenneth A.;</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Sewall Brent J.&option=202" target="_blank" rel="nofollow">Sewall Brent J.;</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Prokkola Jenni M.&option=202" target="_blank" rel="nofollow">Prokkola Jenni M.;</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Turner Gregory G.&option=202" target="_blank" rel="nofollow">Turner Gregory G.;</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Gagnon Marianne F.&option=202" target="_blank" rel="nofollow">Gagnon Marianne F.;</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Lilley Thomas M.&option=202" target="_blank" rel="nofollow">Lilley Thomas M.;</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Paul White J.&option=202" target="_blank" rel="nofollow">Paul White J.;</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Johnson Joseph S.&option=202" target="_blank" rel="nofollow">Johnson Joseph S.;</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Hauer Christopher L.&option=202" target="_blank" rel="nofollow">Hauer Christopher L.;</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Reeder DeeAnn M.&option=202" target="_blank" rel="nofollow">Reeder DeeAnn M.;</a> </p> <span class="z_kbtnclass z_kbtnclassall hoverxs" id="zkzz" style="display: none;">展开▼</span> </div> </li> <li> <div style="display: flex;"> <span class="lefttit">作者单位</span> <div style="position: relative;margin-left: 3px;max-width: 639px;"> <div class="threelineshidden zhankaihshouqi" id="fOrgthree"> <p>Department of BiologyBucknell UniversityLewisburg Pennsylvania;</p> <p>Department of BiologyTemple UniversityPhiladelphia Pennsylvania;</p> <p>Department of BiologyBucknell UniversityLewisburg Pennsylvania;</p> <p>Wildlife Diversity DivisionPennsylvania Game CommissionHarrisburg Pennsylvania;</p> <p>Department of BiologyTemple UniversityPhiladelphia Pennsylvania;</p> <p>Department of BiologyBucknell UniversityLewisburg Pennsylvania;</p> <p>Wisconsin Department of Natural ResourcesMadison Wisconsin;</p> <p>Department of BiologyBucknell UniversityLewisburg Pennsylvania;</p> <p>Department of BiologyTemple UniversityPhiladelphia Pennsylvania;</p> <p>Department of BiologyBucknell UniversityLewisburg Pennsylvania;</p> </div> <span class="z_kbtnclass z_kbtnclassall hoverxs" id="zhdw" style="display: none;">展开▼</span> </div> </div> </li> <li > <span class="lefttit">收录信息</span> <span style="width: 86%;vertical-align: text-top;display: inline-block;"></span> </li> <li> <span class="lefttit">原文格式</span> <span>PDF</span> </li> <li> <span class="lefttit">正文语种</span> <span>eng</span> </li> <li> <span class="lefttit">中图分类</span> <span><a href="https://www.zhangqiaokeyan.com/clc/1285.html" title="生态学（生物生态学）">生态学（生物生态学）;</a></span> </li> <li class="antistop"> <span class="lefttit">关键词</span> <p style="width: 86%;vertical-align: text-top;"> <a style="color: #3E7FEB;" href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=hibernation&option=203" rel="nofollow">hibernation;</a> <a style="color: #3E7FEB;" href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=pathogenesis&option=203" rel="nofollow">pathogenesis;</a> <a style="color: #3E7FEB;" href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=thermoregulatory behaviour&option=203" rel="nofollow">thermoregulatory behaviour;</a> <a style="color: #3E7FEB;" href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=transcriptomics&option=203" rel="nofollow">transcriptomics;</a> <a style="color: #3E7FEB;" href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=white‐nose syndrome&option=203" rel="nofollow">white‐nose syndrome;</a> </p> <div class="translation"> 机译：冬眠;发病机制;热调节行为;转录组织;白鼻综合征; </div> </li> </ul> </div> </div> <div class="literature cardcommon"> <div class="similarity "> <h3 class="all_title" 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<div> <b>4. </b><a class="enjiyixqcontent" href="/academic-journal-cn_modern-flour-milling-industry_thesis/0201296858620.html">藜麦粉对高筋粉糊化特性的影响及藜麦碗托的开发</a> <b>[J]</b> <span> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=延莎&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor"> . 延莎</a> <span> <a href="/journal-cn-9413/" target="_blank" rel="nofollow" class="tuijian_authcolor"> . 现代面粉工业 </a> </span> <span> . 2019</span><span>,第2期</span> </span> </div> </li> <li> <div> <b>5. </b><a class="enjiyixqcontent" href="/academic-journal-cn_furniture-interior-design_thesis/020121921643.html">日本艺术的西传及其对麦金托什设计的影响</a> <b>[J]</b> <span> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=崔敏&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor"> . 崔敏</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=钟希敏&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor">,钟希敏</a> <span> <a href="/journal-cn-9356/" target="_blank" rel="nofollow" class="tuijian_authcolor"> . 家具与室内装饰 </a> </span> <span> . 2006</span><span>,第005期</span> </span> </div> </li> <li> <div> <b>6. </b><a class="enjiyixqcontent" href="/academic-conference-cn_meeting-9387_thesis/020222323706.html">缩小可持续设计教学和研究之间的差距——基于麦金托什建筑学院的经验</a> <b>[C]</b> <span> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Tim Sharpe&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor"> . Tim Sharpe</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=蒂姆·夏普&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor">,蒂姆·夏普</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Sally Stewart&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor">,Sally Stewart</a> <span> <a href="/conference-cn-9387/" target="_blank" rel="nofollow" class="tuijian_authcolor"> . 全球化背景下可持续艺术设计战略国际研讨会 </a> <span> <span> . 2011</span> </span> </div> </li> <li> <div> <b>7. </b><a class="enjiyixqcontent" href="/academic-degree-domestic_mphd_thesis/02031515739.html">维吾尔传统仪式文化视野下的鼓吹乐研究——以喀什麦麦提托合提·亚合甫鼓吹乐班为个案</a> <b>[A] </b> <span> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=古丽加娜提·艾力&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor"> . 古丽加娜提·艾力</a> <span> . 2015</span> </span> </div> </li> </ul> <ul style="display: none;"> <li> <div> <b>1. </b><a class="enjiyixqcontent" href="/patent-detail/06120112949512.html">一种转炉托圈本体耳座固定组对焊接结构及焊接工艺</a> <b>[P]</b> . <span> 中国专利： CN112981037A </span> <span> . 2021-06-18</span> </div> </li> <li> <div> <b>2. </b><a class="enjiyixqcontent" href="/patent-detail/06120214429221.html">一种转炉托圈本体耳座固定组对焊接结构</a> <b>[P]</b> . <span> 中国专利： CN214443726U </span> <span> . 2021-10-22</span> </div> </li> <li> <div> <b>3. </b><a class="enjiyixqcontent" href="/patent-detail/06130435339270.html">composition, bacterium or preparation thereof, method for detecting the presence of an a / e pathogen in a sample, method for eliciting an immune response against an a / e pathogen or a component thereof in an animal, method for reducing colonization of a / e pathogen in an animal, method for reducing the spread of an a / e pathogen in an animal, method for treating or preventing infection by an a / e pathogen, method for attenuating virulence of a / e pathogen, method for selecting a compound that mitigates the virulence of a pathogen and a / e, method for producing an a / e pathogen polypeptide, recombinant polypeptide, isolated nucleic acid molecule , vector, host cell, composition use and kit</a> <b>[P]</b> . <span> 外国专利：  BRPI0415816A </span> <span> . 2006-12-26</span> </div> <p class="zwjiyix translation" style="max-width: initial;height: auto;word-break: break-all;white-space: initial;text-overflow: initial;overflow: initial;"> <span>机译：组合物，细菌或其制备物，用于检测样品中a / e病原体的存在的方法，在动物中引发针对a / e病原体或其成分的免疫应答的方法，用于减少a / e定植的方法动物中的病原体，减少动物中a / e病原体传播的方法，a / e病原体治疗或预防a / e病原体感染的方法，减毒a / e病原体的毒性方法，选择减轻病原体和a / e的毒力，生产a / e病原体多肽的方法，重组多肽，分离的核酸分子，载体，宿主细胞，组合物用途和试剂盒 </span> </p> </li> <li> <div> <b>4. </b><a class="enjiyixqcontent" href="/patent-detail/06130451851682.html">STRAIN OF BACTERIUM FOR PROPHYLAXIS OF FRUITS AND VEGETABLES FUNGAL SICKNESS AFTER HARVEST AND PREPARING ANTIBIOTICS FOR INHIBITION OF PATHOGENS OF THE ABOVE INDICATED SICKNESSES (VARIANTS), STRAIN OF BACTERIUM FOR PROPHYLAXIS OF FUNGAL SICKNESS IN FRUITS AND VEGETABLES AFTER HARVEST (VARIANTS), AN AQUEOUS SUSPENSION OF MICROORGANISM FOR INHIBITION OF PATHOGENS OF FUNGAL SICKNESSES IN FRUITS AND VEGETABLES, A METHOD OF PROPHYLAXIS OF FUNGAL SICKNESSES IN VEGETABLES AND/OR FRUITS AFTER HARVEST, AN ANTIBIOTIC USED FOR INHIBITION OF PATHOGEN OF FUNGAL SICKNESS IN FRUITS AND VEGETABLES AFTER HARVEST</a> <b>[P]</b> . <span> 外国专利：  RU2126210C1 </span> <span> . 1999-02-20</span> </div> <p class="zwjiyix translation" style="max-width: initial;height: auto;word-break: break-all;white-space: initial;text-overflow: initial;overflow: initial;"> <span>机译：收割后的菌体和蔬菜真菌病原菌的细菌菌株，以及为抑制上述病原菌（变种）的抗菌剂，为菌落的小肠细菌（小肠）的真菌和小肠粘膜的细菌抑制水果和蔬菜中真菌病原菌的微生物的研究，收割后蔬菜和/或水果中真菌病原体的抑菌方法，用于抑制真菌和真菌病原菌病原菌的抗生素 </span> </p> </li> <li> <div> <b>5. </b><a class="enjiyixqcontent" href="/patent-detail/06130446859321.html">Processes for detecting a mutation in the nucleic acid to detect fungal and fungal resistance to an analogue of estobilurina,Fungal DNA sequence encoding all or part of a proteu00ecna of cytochrome b, cytochrome b proteu00ecna fungal.The allele specific oligonucleotu00ecdeo capable of connecting to a sequence of fungal nucleic acid, initiator of diagnosis or diagnostic oligonucleotu00ecdeo capable of connecting to a template.One or more diagnostic primers, probe the allele specific oligonucleotu00ecdeo, diagnostic kit to detect fungal pathogen resistance, process plant, a fungicide.To detect and quantify the frequency of mutation, to select a fungicide active and their nu00ecveis optimal implementation, and to control the fungal infection of a collection, and,A computer legu00ecvel</a> <b>[P]</b> . <span> 外国专利：  BR0010163A </span> <span> . 2002-01-15</span> </div> <p class="zwjiyix translation" style="max-width: initial;height: auto;word-break: break-all;white-space: initial;text-overflow: initial;overflow: initial;"> <span>机译：用于检测核酸突变的方法，以检测对食管胆囊炎类似物的真菌和真菌抗性，真菌DNA序列编码全部或部分细胞色素b蛋白，细胞色素b蛋白真菌，等位基因特异性寡核苷酸能够连接到真菌核酸序列的诊断或诊断寡核苷酸的启动子，能够连接到模板。一个或多个诊断引物，探查等位基因特异性寡核苷酸，诊断试剂盒以检测真菌病原体抗性，加工厂要检测和量化突变的频率，选择一种活性杀菌剂及其最佳实施方案，控制一个集合体的真菌感染以及计算机支路， </span> </p> </li> </ul> </div> </div> </div> <div class="theme cardcommon" style="overflow: auto;display:none"> <h3 class="all_title" id="enpatent55">相关主题</h3> <ul id="subject"> </ul> </div> </div> </div> </div> <div class="right rightcon"> <div class="details_img cardcommon clearfix" style="margin-bottom: 10px;display:none;" > </div> </div> </div> <div id="thesis_get_original1" class="downloadBth" style="bottom: 19px;z-index: 999;" onclick="ywcd('0704023741202','4',7,2,1,'',this,24)" class="delivery" prompt="010401" title="通过人工服务将文献原文发送至邮箱" >获取原文</div> <div class="journalsub-pop-up" style="display: none"> <div class="journal-sub"> <h2>期刊订阅</h2> <img src="https://cdn.zhangqiaokeyan.com/img/loginclose.png" alt="关闭" onclick="$('.journalsub-pop-up').hide()"> <p 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