• 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Addiction biology >CNR1 gene polymorphisms in addictive disorders: a systematic review and a meta-analysis.
【24h】

CNR1 gene polymorphisms in addictive disorders: a systematic review and a meta-analysis.

机译：成瘾性疾病中的CNR1基因多态性：系统评价和荟萃分析。

获取原文
获取原文并翻译 | 示例
       
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

The aim of the present work was to systematically review all association studies of cannabis receptor 1 (CNR1) polymorphisms with dependence syndrome and to perform a meta-analysis. Odds ratios (ORs) were estimated by contrasting the ratio of counts of the 'high risk' versus 'low risk' alleles in cases with dependence versus controls. Studies were analyzed by random-effects meta-analysis using pooled OR. Eleven full text articles met our eligibility criteria and nine meta-analyses were performed on three polymorphisms of CNR1: rs1049353, rs806379 and the AAT repeat. Of these, only the AAT polymorphism showed a significant association with illicit substance dependence but only in the Caucasian population samples and using a risk allele definition of >/= 16 repeats. Our analysis showed a small effect size (OR = 1.55, P = 0.045), with strong heterogeneity (Q = 19.87, P < 0.01 with I(2) = 85%). In line with the polygenic model, our meta-analysis supports a minor implication for CNR1 AAT polymorphism in illicit substance dependence vulnerability. Further studies in well-phenotyped samples and using more polymorphisms are needed to conclude on the actual influence of cannabinoid receptor polymorphisms.
机译：本工作的目的是系统回顾大麻受体1（CNR1）多态性与依赖综合征的所有关联研究，并进行荟萃分析。通过比较在有依赖性和对照的情况下“高风险”与“低风险”等位基因计数的比率来估计几率（OR）。使用合并的OR通过随机效应荟萃分析对研究进行分析。共有11篇全文文章符合我们的资格标准，并且对CNR1的三种多态性进行了九次荟萃分析：rs1049353，rs806379和AAT重复序列。其中，仅AAT多态性显示与非法物质依赖性显着相关，但仅在高加索人群样本中，并且使用风险等位基因定义为> / = 16个重复。我们的分析显示出较小的效应量（OR = 1.55，P = 0.045），具有很强的异质性（Q = 19.87，P <0.01，I（2）= 85％）。与多基因模型相一致，我们的荟萃分析支持CNR1 AAT多态性对非法物质依赖脆弱性的影响很小。需要进一步研究表型良好的样品并使用更多的多态性来得出大麻素受体多态性的实际影响的结论。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号