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首页> 外文期刊>Addiction biology >Neural correlates of craving and resisting craving for tobacco in nicotine dependent smokers.
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Neural correlates of craving and resisting craving for tobacco in nicotine dependent smokers.

机译：尼古丁依赖性吸烟者对烟草渴望与抵制渴望的神经相关性。

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Craving is a significant factor which can lead to relapse during smoking quit attempts. Attempts to resist urges to smoke during cue-elicited craving have been shown to activate regions in the brain associated with decision-making, anxiety regulation and visual processing. In this study, 32 treatment-seeking, nicotine-dependent smokers viewed blocks of smoking and neutral cues alternating with rest periods during magnetic resonance imaging scanning in a 3T Siemens scanner (Siemens AG, Erlangen, Bavaria, Germany). While viewing cues or control images, participants were instructed either to 'allow yourself to crave' or 'resist craving.' Data were analyzed with FSL 4.1.5, focused on the smoking cues versus neutral cues contrast, using cluster thresholding (Z > 2.3 and corrected cluster threshold of P = 0.05) at the individual and group levels. During the Crave condition, activation was seen on the left anterior cingulated cortex (LACC), medial prefrontal cortex, left middle cingulate gyrus, bilateral posterior cingulated gyrus and bilateral precuneus, areas associated with attention, decision-making and episodic memory. The LACC and areas of the prefrontal cortex associated with higher executive functioning were activated during the Resist condition. No clear distinctions between group crave and resist analyses as a whole were seen without taking into account specific strategies used to resist the urge to smoke, supporting the idea that craving is associated with some degree of resisting the urge to smoke, and trying to resist is almost always accompanied by some degree of craving. Different strategies for resisting, such as distraction, activated different regions. Understanding the underlying neurobiology of resisting craving to smoke may identify new foci for treatments.
机译：渴望是一个重要因素，可能导致戒烟过程中复发。在提示引起的渴望过程中，试图抵制吸烟的尝试已被证明可以激活大脑中与决策，焦虑调节和视觉处理相关的区域。在这项研究中，在3T西门子扫描仪（Siemens AG，​​埃尔兰根，巴伐利亚，德国）中进行磁共振成像扫描期间，有32位寻求治疗的依赖尼古丁的吸烟者观察到吸烟和中性线索与休息时间交替出现。在查看提示或控制图像时，指示参与者“允许自己渴望”或“抵抗渴望”。使用FSL 4.1.5分析数据，重点是吸烟提示与中性提示的对比，使用个体和群体水平的聚类阈值（Z> 2.3和校正的聚类阈值P = 0.05）。在Crave病情期间，在左前扣带回皮层（LACC），内侧前额叶皮层，左中扣带回，中间后扣带回和双侧前突，与注意，决策和情景记忆相关的区域可见激活。在抵抗状态下，LACC和前额叶皮层与高级执行功能相关的区域被激活。在没有考虑用于抵制吸烟冲动的特定策略，支持渴望与某种程度的抵制吸烟冲动相关的想法的情况下，整体上对小组的渴望与抵制分析之间没有明显的区别，这表明几乎总是伴随着某种程度的渴望。不同的抵抗策略（例如分散注意力）激活了不同区域。了解抵抗吸烟的潜在神经生物学可能会发现新的治疗重点。

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