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首页> 外文期刊>Addiction biology >Repeated moderate-dose ethanol bouts impair cognitive function in Wistar rats
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Repeated moderate-dose ethanol bouts impair cognitive function in Wistar rats

机译：重复中剂量乙醇发作损害Wistar大鼠的认知功能

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摘要

The effects of repeated, intermittent administration of a moderate dose of ethanol (3.4 g/kg/day × 6 days, intragastrically via gavages) on cognitive function were examined in male Wistar rats. No significant differences in weight gain between the ethanol- and water-treated rats were found. Analysis of physical dependence revealed no signs of spontaneous withdrawal, whereas withdrawal signs exacerbated by Ro15-4513, an inverse benzodiazepine agonist, were apparent 5 hours but not 24 hours after the cessation of ethanol treatment. Spatial learning and memory, as assessed in the Barnes maze, were impaired 3-6 days following the treatment but recovered by the 11th-14th days. Reversal learning, however, was impaired throughout the 2-week observation period. Thus, bouts of moderate-dose ethanol administration transiently impair spatial learning and memory, and promote cognitive inflexibility. The employed ethanol exposure paradigm may provide a model of human cognitive deficits associated with alcohol binge drinking.
机译：在雄性Wistar大鼠中检查了重复，间歇性给予适量乙醇（3.4 g / kg /天×6天，通过灌胃法在胃内）对认知功能的影响。在乙醇和水处理的大鼠之间，体重增加没有显着差异。身体依赖性的分析显示没有自发戒断的迹象，而逆转苯二氮卓激动剂Ro15-4513（在停止乙醇治疗后5小时而不是24小时后）加剧了戒断迹象。在治疗后3-6天，在Barnes迷宫中评估的空间学习和记忆能力受损，但在第11-14天恢复。然而，在整个两周的观察期内，逆向学习受到了损害。因此，适量乙醇的发作会暂时损害空间学习和记忆，并促进认知僵化。所采用的乙醇暴露范例可以提供与酗酒有关的人类认知缺陷的模型。

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