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首页> 外文期刊>Addiction biology >COMT and ALDH2 polymorphisms moderate associations of implicit drinking motives with alcohol use
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COMT and ALDH2 polymorphisms moderate associations of implicit drinking motives with alcohol use

机译：COMT和ALDH2多态性可缓解内隐饮酒动机与饮酒的关联

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Dual process models of addiction emphasize the importance of implicit (automatic) cognitive processes in the development and maintenance of substance use behavior. Although genetic influences are presumed to be relevant for dual process models, few studies have evaluated this possibility. The current study examined two polymorphisms with functional significance for alcohol use behavior (COMT Val158Met and ALDH2*2) in relation to automatic alcohol cognitions and tested additive and interactive effects of genotype and implicit cognitions on drinking behavior. Participants were college students (n = 69) who completed Implicit Association Tasks (IATs) designed to assess two classes of automatic drinking motives (enhancement motives and coping motives). Genetic factors did not show direct associations with IAT measures; however, COMT and ALDH2 moderated associations of implicit coping motives with drinking outcomes. Interaction effects indicated that associations of implicit motives with drinking outcomes were strongest in the context of genetic variants associated with relatively higher risk for alcohol use (COMT Met and ALDH2*1). Associations of genotype with drinking behavior were observed for ALDH2 but not COMT. These findings are consistent with the possibility that genetic risk or protective factors could potentiate or mitigate the influence of reflexive cognitive processes on drinking behavior, providing support for the evaluation of genetic influences in the context of dual process models of addiction.
机译：成瘾的双重过程模型强调了内隐（自动）认知过程在物质使用行为的发展和维持中的重要性。尽管遗传影响被认为与双过程模型有关，但很少有研究评估这种可能性。当前的研究检查了两种与酒精使用行为具有功能性意义的多态性（COMT Val158Met和ALDH2 * 2），这些多态性与自动酒精认知相关，并测试了基因型和内隐认知对饮酒行为的加性和交互作用。参加者是大学生（n = 69），他们完成了隐式联想任务（IAT），旨在评估两类自动饮酒动机（增强动机和应对动机）。遗传因素未显示与IAT措施有直接关联;然而，COMT和ALDH2调节了内隐应对动机与饮酒结果的关联。相互作用的影响表明，在与较高饮酒风险相关的遗传变异的背景下，内隐动机与饮酒结果的关联最强（COMT Met和ALDH2 * 1）。观察到ALDH2基因型与饮酒行为的相关性，而COMT没有。这些发现与遗传风险或保护因素可能增强或减轻自反性认知过程对饮酒行为的影响相一致，为成瘾的双过程模型背景下的遗传影响评估提供了支持。

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