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首页> 外文期刊>Mycologia >Chloroacetamide derivatives as a promising topical treatment for fungal skin infections
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Chloroacetamide derivatives as a promising topical treatment for fungal skin infections

机译:氯乙酰胺衍生物作为真菌皮肤感染的有前途的局部处理

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摘要

The aim of this study was to evaluate the antifungal potential of 11 chloroacetamide derivatives and derivative incorporated into a film-forming system (FFS) as a potential alternative for the topical treatment of superficial and skin mycoses. The minimum inhibitory concentration (MIC) evaluation followed Clinical and Laboratory Standards Institute protocols M27-A3 (Candida) and M28-A2 (dermatophytes). Compounds 2, 3, and 4 were the most effective against Candida species (MIC range: 25-50 mu g/mL) and dermatophytes (MIC range: 3.12-50 mu g/mL). Compound 2 maintained its antifungal activity when incorporated in a FFS, with MIC values equivalent to the free compound. In addition, the compound does not act through complexation with ergosterol, suggesting that it may act on other targets of the fungal cell membrane. Chloroacetamide derivatives presented anti-Candida and anti-dermatophytic effectiveness. The FFS containing compound 2 has shown to be superior to traditional topical treatment of superficial and cutaneous fungal infections. It was found that these new chemical entities, with their applicability, are an excellent alternative to the topical treatment of fungal skin infections.
机译:本研究的目的是评估11种氯酰胺衍生物的抗真菌潜力和掺入成膜系统(FF)的衍生物,作为浅表和皮​​肤肌肉术的局部处理的潜在替代方案。最小抑制浓度(MIC)评估遵循临床和实验室标准协定协议M27-A3(Candida)和M28-A2(Dermatophytes)。化合物2,3和4是最有效的念珠菌物种(MIC范围:25-50μg/ ml)和Dermatophytes(MIC范围:3.12-50μg/ ml)。当在FF中掺入时,化合物2保持其抗真菌活性,MIC值相当于游离化合物。此外,该化合物不能通过与Ergosterol溶胶的络合作用,表明它可以作用于真菌细胞膜的其他靶标。氯乙酰胺衍生物呈现抗念珠菌和抗皮肤病的效果。含有化合物2的FFS显示出优于浅表和皮肤真菌感染的传统局部处理。发现这些新化学实体以其适用性,是对真菌皮肤感染的局部治疗的优异替代品。

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