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首页> 外文期刊>Addictive behaviors >Treatment or 'high': Benzodiazepine use in patients on injectable heroin or oral opioids
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Treatment or 'high': Benzodiazepine use in patients on injectable heroin or oral opioids

机译：治疗或“高剂量”：苯二氮卓类药物在注射海洛因或口服阿片类药物的患者中的使用

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摘要

Benzodiazepine (BZD) use is widespread among opioid-maintained patients worldwide. We conducted a cross-sectional survey to investigate motives and patterns of BZD use and psychiatric comorbidity in a convenience sample of patients (n = 193) maintained on oral opioid agonists or diacetylmorphine (DAM). Prolonged BZD use and high-risk behaviors like parenteral use were common. After principal component analysis, motives were divided into those related to negative affect regulation, positive affect regulation (i.e. reward-seeking) and somato-medical problems. Negative affect regulation and somato-medical motives were associated with prolonged use. Psychiatric comorbidity was associated with several self-therapeutic motives, most importantly to lose anxiety. Patients maintained on DAM were more likely to be ex-users of BZD and report high positive affect regulation. Therefore, patients maintained on different agonists may have deviating motives for BZD use, which could be of importance when addressing this issue. Treatment of psychiatric comorbidity, in particular anxiety, depressive and sleeping disorders, may be helpful in reducing BZD use, particularly in patients maintained on oral opioids.
机译：苯二氮卓（BZD）的使用在全世界阿片类药物维持患者中广泛存在。我们进行了一项横断面调查，以调查方便样本中口服阿片类激动剂或二乙酰吗啡（DAM）的患者（n = 193）中使用BZD的动机和方式以及精神病合并症。长期使用BZD和高风险行为（如肠胃外使用）很常见。经过主成分分析后，动机被分为与消极情绪调节，积极情绪调节（即奖励寻求）和躯体医学问题有关的动机。负面影响调节和身体医学动机与长期使用有关。精神病合并症与几种自我治疗动机有关，最重要的是减轻焦虑。维持DAM的患者更有可能是BZD的前使用者，并报告了高度积极的情绪调节。因此，维持不同激动剂的患者可能会有不同的动机使用BZD，这在解决该问题时可能很重要。治疗精神病合并症，特别是焦虑症，抑郁症和睡眠障碍，可能有助于减少BZD的使用，尤其是对口服阿片类药物的患者。

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