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首页> 外文期刊>Nature reviews. Urology >Towards clinical application of tissue engineering for erectile penile regeneration
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Towards clinical application of tissue engineering for erectile penile regeneration

机译：临床应用组织工程对勃起阴茎再生的临床应用

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摘要

Penile wounds after traumatic and surgical amputation require reconstruction in the form of autologous tissue transfers. However, currently used techniques are associated with high infection rates, implant erosion and donor site morbidity. The use of tissue-engineered neocorpora provides an alternative treatment option. Contemporary tissue-engineering strategies enable the seeding of a biomaterial scaffold and subsequent implantation to construct a neocorpus. Tissue engineering of penile tissue should focus on two main strategies: first, correcting the volume deficit for structural integrity in order to enable urinary voiding in the standing position and second, achieving erectile function for sexual activity. The functional outcomes of the neocorpus can be addressed by optimizing the use of stem cells and scaffolds, or alternatively, the use of gene therapy. Current research in penile tissue engineering is largely restricted to rodent and rabbit models, but the use of larger animal models should be considered as a better representation of the anatomical and physiological function in humans. The development of a cell-seeded scaffold to achieve and maintain erection continues to be a considerable challenge in humans. However, advances in penile tissue engineering show great promise and, in combination with gene therapy and surgical techniques, have the potential to substantially improve patient outcomes.
机译：创伤性和手术截肢后的阴茎伤口需要以自体组织转移的形式重建。然而，目前使用的技术与高感染率，植入物侵蚀和供体现象的发病率有关。使用组织工程的Neocorpora提供替代处理选项。当代组织 - 工程策略使得播种生物材料支架和随后的植入来构建新型植物。阴茎组织的组织工程应关注两个主要策略：第一，纠正结构完整性的体积缺陷，以便在站立位置和第二，实现性活动的勃起功能。通过优化干细胞和支架的使用，或者可以使用基因治疗的使用来解决新频道的功能结果。阴茎组织工程目前的研究主要限于啮齿动物和兔子模型，但使用较大的动物模型应该被认为是人类解剖学和生理功能的更好代表性。蜂窝种子脚手架实现和维持勃起的发展仍然是人类的相当大的挑战。然而，阴茎组织工程的进步表现出很大的希望，并且结合基因治疗和外科手术技术，有可能显着改善患者的结果。

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