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首页> 外文期刊>Neurobiology of learning and memory >Cortico-hippocampal GluN2B is essential for efficient visual-spatial discrimination learning in a touchscreen paradigm
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Cortico-hippocampal GluN2B is essential for efficient visual-spatial discrimination learning in a touchscreen paradigm

机译：Cortico-hippodampal Glun2B对于触摸屏范式中有效的视觉空间歧视学习至关重要

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Discrimination of similar spatial locations, an important feature of episodic memory, has traditionally been measured via delayed nonmatching-to-location tasks. Recently, we and others have demonstrated that touchscreen-based Trial Unique Nonmatching-to-Location (TUNL) tasks are sensitive to lesions of the dorsal hippocampus in the mouse. Previously we have shown that loss of the GluN2B subunit of the N-methyl-D-aspartate (NMDA) receptor in the dorsal CA1 and throughout the cortex impairs hippocampal-dependent water maze and fear conditioning paradigms. We investigated whether loss of GluN2B would alter performance of visual-spatial discrimination learning in a delay- or separation-dependent manner. GluN2B null mutants displayed initial impairments in accuracy on the easiest training variant of TUNL that were overcome with training. Loss of GluN2B also impaired performance on a problem series where delay and separation were systematically varied. We also observed a training-dependent effect on performance. Mutant mice that received extensive training performed similar to control mice when challenged on a variable delay and variable separation problem, while those that received minimal training were impaired across all delays and separations. Together, these data demonstrate that GluN2B in the dorsal CA1 and cortex are essential for efficient visual-spatial discrimination learning on the TUNL task. Further, training effects on performance in mutant mice suggest that alterations in synaptic plasticity after GluN2B loss may underlie intra-versus inter-session learning.
机译：传统上通过延迟的非匹配到位置任务来测量类似空间位置的相似空间位置的辨别。最近，我们和其他人已经证明，基于触摸屏的试验独特的非匹配到位置（TUNL）任务对鼠标中背海马的病变敏感。以前我们已经表明，在背部Ca1和整个皮质中的N-甲基-D-天冬氨酸（NMDA）受体的GLUN2B亚基的损失损失了海马依赖的水迷宫和恐惧调节范式。我们调查了GLUN2B的丧失是否会以延迟或分离依赖的方式改变视觉空间歧视学习的性能。 GLUN2B NULL突变体的初始损伤准确造成训练的最简单训练变体的准确性。 GLUN2B的损失在系统变化的问题系列上的性能下也受损。我们还观察到对性能的培训依赖性影响。当在可变延迟和可变分离问题上攻击时，接受广泛训练的突变小鼠在对照小鼠上进行了相似的培训，而在所有延迟和分离中受到最小培训的那些。这些数据在一起表明，背部CA1和皮层中的GLUN2B对于TUNL任务的有效视觉空间歧视学习是必不可少的。此外，对突变小鼠的性能的培训效果表明GLUN2B损失后突触可塑性的改变可能是与会话间学习中的影响。

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