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首页> 外文期刊>Neuron >Interactions between the Ig-Superfamily Proteins DIP-alpha and Dpr6/10 Regulate Assembly of Neural Circuits
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Interactions between the Ig-Superfamily Proteins DIP-alpha and Dpr6/10 Regulate Assembly of Neural Circuits

机译：IG-Superfamily蛋白质DIP-alpha和DPR6 / 10调节神经电路组装之间的相互作用

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摘要

Drosophila Dpr (21 paralogs) and DIP proteins (11 paralogs) are cell recognition molecules of the immunoglobulin superfamily (IgSF) that form a complex protein interaction network. DIP and Dpr proteins are expressed in a synaptic layer-specific fashion in the visual system. How interactions between these proteins regulate layer-specific synaptic circuitry is not known. Here we establish that DIP-alpha and its interacting partners Dpr6 and Dpr10 regulate multiple processes, including arborization within layers, synapse number, layer specificity, and cell survival. We demonstrate that heterophilic binding between Dpr6/10 and DIP-alpha and homophilic binding between DIP-alpha proteins promote interactions between processes in vivo. Knockin mutants disrupting the DIP/Dpr binding interface reveal a role for these proteins during normal development, while ectopic expression studies support an instructive role for interactions between DIPs and Dprs in circuit development. These studies support an important role for the DIP/Dpr protein interaction network in regulating celltype-specific connectivity patterns.
机译：果蝇DPR（21个旁系蛋白酶）和浸渍蛋白（11个旁系蛋白酶）是免疫球蛋白超家族（IGSF）的细胞识别分子，其形成复杂的蛋白质相互作用网络。 DIP和DPR蛋白以视觉系统中的特定突触层的方式表示。这些蛋白质之间的相互作用如何调节层特异性突触电路。在这里，我们建立了DIP-alpha及其互动伙伴DPR6和DPR10调节多个过程，包括层内，突触数，层特异性和细胞存活率。我们证明DPR6 / 10和浸α蛋白之间的DPR6 / 10和浸α和嗜合性结合之间的异质结合促进体内过程之间的相互作用。敲击浸入浸渍/ DPR结合界面的突变突变体揭示了在正常发育过程中对这些蛋白质的作用，而异位表达研究支持在电路开发中的倾角和DPR之间的相互作用进行指导性作用。这些研究支持DIP / DPR蛋白相互作用网络在调节细胞系特异性连接模式中的重要作用。

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  • 来源
    《Neuron》 |2018年第6期|共22页
  • 作者

    Xu Shuwa; Xiao Qi; Cosmanescu Filip; Sergeeva Alina P.; Yoo Juyoun; Lin Ying; Katsamba Phinikoula S.; Ahlsen Goran; Kaufman Jonathan; Linaval Nikhil T.; Lee Pei-Tseng; Bellen Hugo J.; Shapiro Lawrence; Honig Barry; Tan Liming; Zipursky S. Lawrence;

  • 作者单位

    Univ Calif Los Angeles David Geffen Sch Med Howard Hughes Med Inst Dept Biol Chem Los Angeles;

    Univ Calif Los Angeles David Geffen Sch Med Howard Hughes Med Inst Dept Biol Chem Los Angeles;

    Columbia Univ Dept Biochem &

    Mol Biophys New York NY 10032 USA;

    Columbia Univ Dept Biochem &

    Mol Biophys New York NY 10032 USA;

    Univ Calif Los Angeles David Geffen Sch Med Howard Hughes Med Inst Dept Biol Chem Los Angeles;

    Univ Calif Los Angeles David Geffen Sch Med Howard Hughes Med Inst Dept Biol Chem Los Angeles;

    Columbia Univ Dept Biochem &

    Mol Biophys New York NY 10032 USA;

    Columbia Univ Dept Biochem &

    Mol Biophys New York NY 10032 USA;

    Univ Calif Los Angeles David Geffen Sch Med Howard Hughes Med Inst Dept Biol Chem Los Angeles;

    Univ Calif Los Angeles David Geffen Sch Med Howard Hughes Med Inst Dept Biol Chem Los Angeles;

    Baylor Coll Med Howard Hughes Med Inst Dept Mol &

    Human Genet Houston TX 77030 USA;

    Baylor Coll Med Howard Hughes Med Inst Dept Mol &

    Human Genet Houston TX 77030 USA;

    Columbia Univ Dept Biochem &

    Mol Biophys New York NY 10032 USA;

    Columbia Univ Dept Biochem &

    Mol Biophys New York NY 10032 USA;

    Univ Calif Los Angeles David Geffen Sch Med Howard Hughes Med Inst Dept Biol Chem Los Angeles;

    Univ Calif Los Angeles David Geffen Sch Med Howard Hughes Med Inst Dept Biol Chem Los Angeles;

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  • 正文语种 eng
  • 中图分类 神经病学;
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