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首页> 外文期刊>Neuron >Activity-Dependent Gating of Parvalbumin Interneuron Function by the Perineuronal Net Protein Brevican
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Activity-Dependent Gating of Parvalbumin Interneuron Function by the Perineuronal Net Protein Brevican

机译：PerineUronal Net蛋白Brevican的Parvalbumise Interpeuron功能的活性依赖性网

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摘要

Activity-dependent neuronal plasticity is a fundamental mechanism through which the nervous system adapts to sensory experience. Several lines of evidence suggest that parvalbumin (PV+) interneurons are essential in this process, but the molecular mechanisms underlying the influence of experience on interneuron plasticity remain poorly understood. Perineuronal nets (PNNs) enwrapping PV+ cells are long-standing candidates for playing such a role, yet their precise contribution has remained elusive. We show that the PNN protein Brevican is a critical regulator of interneuron plasticity. We find that Brevican simultaneously controls cellular and synaptic forms of plasticity in PV+ cells by regulating the localization of potassium channels and AMPA receptors, respectively. By modulating Brevican levels, experience introduces precise molecular and cellular modifications in PV+ cells that are required for learning and memory. These findings uncover a molecular program through which a PNN protein facilitates appropriate behavioral responses to experience by dynamically gating PV+ interneuron function.
机译：活性依赖性神经元塑性是神经系统适应感官体验的基本机制。几种证据表明，帕瓦尔白蛋白（PV +）中间核在这一过程中至关重要，但基本的分子机制对中间核塑性经验的影响仍然很清楚。颈椎网（PNNS）包裹PV +细胞是在竞争此类作用的长期候选者，但它们的确切贡献仍然难以捉摸。我们表明PNN蛋白Brevican是临界稳压器的临界调节器。我们发现，通过分别调节钾通道和AMPA受体的定位，Brevican同时通过调节钾通道和AMPA受体的定位来控制PV +细胞中的塑性度和突触形式。通过调制Brevican水平，经验在学习和记忆所需的PV +电池中引入了精确的分子和细胞修饰。这些发现发现PNN蛋白通过该分子程序通过这种分子程序通过动态浇注PV + Interneuron功能来促进适当的行为反应对经验。

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  • 来源
    《Neuron》 |2017年第3期|共27页
  • 作者

    Favuzzi Emilia; Marques-Smith Andre; Deogracias Ruben; Winterflood Christian M.; Sanchez-Aguilera Alberto; Mantoan Laura; Maeso Patricia; Fernandes Cathy; Ewers Helge; Rico Beatriz;

  • 作者单位

    Kings Coll London Inst Psychiat Psychol &

    Neurosci Ctr Dev Neurobiol London SE1 1UL England;

    Kings Coll London Inst Psychiat Psychol &

    Neurosci Ctr Dev Neurobiol London SE1 1UL England;

    Kings Coll London Inst Psychiat Psychol &

    Neurosci Ctr Dev Neurobiol London SE1 1UL England;

    Kings Coll London Randall Div Cell &

    Mol Biophys London SE1 1UL England;

    Kings Coll London Inst Psychiat Psychol &

    Neurosci Ctr Dev Neurobiol London SE1 1UL England;

    Kings Coll London NHS Fdn Trust Clin Neurosci Dept Denmark Hill London SE5 9RS England;

    Kings Coll London Inst Psychiat Psychol &

    Neurosci Ctr Dev Neurobiol London SE1 1UL England;

    Kings Coll London MRC Ctr Neurodev Disorders London SE1 1UL England;

    Kings Coll London Randall Div Cell &

    Mol Biophys London SE1 1UL England;

    Kings Coll London Inst Psychiat Psychol &

    Neurosci Ctr Dev Neurobiol London SE1 1UL England;

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  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类 神经病学;
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